INTESTINAL M-CELLS - A PATHWAY FOR ENTRY OF REOVIRUS INTO THE HOST
INTESTINAL M-CELLS - A PATHWAY FOR ENTRY OF REOVIRUS INTO THE HOST
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DOI：
10.1126/science.6259737
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发表时间：
1981-01-01
期刊：
影响因子：
56.9
通讯作者：
FIELDS, BN
中科院分区：
文献类型：
--
作者：
WOLF, JL;RUBIN, DH;FIELDS, BN
将呼肠孤病毒I型接种到小鼠肠腔中30分钟后，发现病毒粘附在肠M细胞的表面，但未粘附在其他上皮细胞的表面。在1小时内，在M细胞胞质中观察到病毒，并与邻近M细胞的细胞间隙中的单核细胞相关。M细胞显然是呼肠孤病毒穿透肠上皮的部位。
By 30 min after inoculation of reovirus type I into the intestinal lumen of the mouse, viruses were found adhering to the surface of intestinal M cells but not other epithelial cells. Within 1 h, viruses were seen in the M cell cytoplasm and were associated with mononuclear cells in the intercellular space adjacent to the M cell. M cells are apparently the site where reovirus penetrates the intestinal epithelium.