Swedish traveller with Plasmodium knowlesi malaria after visiting Malaysian Borneo
Swedish traveller with Plasmodium knowlesi malaria after visiting Malaysian Borneo
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DOI：
10.1186/1475-2875-8-15
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发表时间：
2009-01-16
期刊：
影响因子：
3
通讯作者：
Singh, Balbir
中科院分区：
文献类型：
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作者：
Bronner, Ulf;Divis, Paul C. S.;Singh, Balbir
诺氏疟原虫（Plasmodium knowlesi）通常在自然界中的猕猴中发现，最近被认为是导致东南亚人群疟疾的第五种疟原虫。2006年10月，一名瑞典男子从马来西亚婆罗洲短暂访问返回后患病。他的诺氏疟原虫感染没有使用疟疾快速诊断测试检测出来，但通过PCR和分子表征得到了证实。他对甲氟喹治疗反应迅速。有必要用来自诺氏疟原虫疟疾患者的进一步样本对快速诊断试剂盒进行评价，因为由于诺氏疟原虫的快速生长和可能危及生命的性质，对疑似病例的早期识别和适当的抗疟疾治疗至关重要。医生应该意识到，诺氏菌感染是发热旅行者的重要鉴别诊断，近期有东南亚森林地区旅行史，包括快速诊断测试呈阴性的短期旅行者。
Plasmodium knowlesi is typically found in nature in macaques and has recently been recognized as the fifth species of Plasmodium causing malaria in human populations in south-east Asia. A case of knowlesi malaria is described in a Swedish man, who became ill after returning from a short visit to Malaysian Borneo in October 2006. His P. knowlesi infection was not detected using a rapid diagnostic test for malaria, but was confirmed by PCR and molecular characterization. He responded rapidly to treatment with mefloquine. Evaluation of rapid diagnostic kits with further samples from knowlesi malaria patients are necessary, since early identification and appropriate anti-malarial treatment of suspected cases are essential due to the rapid growth and potentially life-threatening nature of P. knowlesi. Physicians should be aware that knowlesi infection is an important differential diagnosis in febrile travellers, with a recent travel history to forested areas in south-east Asia, including short-term travellers who tested negative with rapid diagnostic tests.