Encoding of 3D Head Orienting Movements in the Primary Visual Cortex
Encoding of 3D Head Orienting Movements in the Primary Visual Cortex
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DOI：
10.1016/j.neuron.2020.07.014
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发表时间：
2020-11-11
期刊：
影响因子：
16.2
通讯作者：
Cox, David
中科院分区：
文献类型：
--
作者：
Guitchounts, Grigori;Masis, Javier;Cox, David
动物通过产生复杂的运动模式，在三维空间中进化，积极地对感官世界进行采样。这些运动是否或如何影响感觉皮质区域的神经元活动仍然很大程度上未知，因为大多数探索运动相关调节的实验都是在头部固定的动物身上进行的。在这里，我们展示了3D头部定向运动（HOMs）以一种方向特定的方式调节初级视觉皮层（V1）的活动，这种方式也依赖于光。我们确定了支持这种调制的两个重叠的运动方向调谐神经元群，其中一个在黑暗中调谐方向，另一个在光明中调谐方向。虽然整体运动增强了V1对视觉刺激的反应，但HOMs抑制了反应。我们证明V1从次级运动皮层接收与定向相关的运动干扰拷贝，这参与了HOMs的控制。这些结果支持脑功能的预测编码理论，并揭示了三维运动在塑造感觉皮质动力学中的普遍作用。
Animals actively sample the sensory world by generating complex patterns of movement that evolve in three dimensions. Whether or how such movements affect neuronal activity in sensory cortical areas remains largely unknown, because most experiments exploring movement-related modulation have been performed in head-fixed animals. Here, we show that 3D head-orienting movements (HOMs) modulate primary visual cortex (V1) activity in a direction-specific manner that also depends on light. We identify two overlapping populations of movement-direction-tuned neurons that support this modulation, one of which is direction tuned in the dark and the other in the light. Although overall movement enhanced V1 responses to visual stimulation, HOMs suppressed responses. We demonstrate that V1 receives a motor efference copy related to orientation from secondary motor cortex, which is involved in controlling HOMs. These results support predictive coding theories of brain function and reveal a pervasive role of 3D movement in shaping sensory cortical dynamics.