Suppression of drinking but not feeding by central eledoisin and physalaemin in the rat.
Suppression of drinking but not feeding by central eledoisin and physalaemin in the rat.
复制标题
中枢草红素和酸浆素抑制大鼠饮水但不摄食。
DOI：
10.1016/s0195-6663(86)80042-3
复制
发表时间：
1986
期刊：
影响因子：
5.4
通讯作者：
Epstein,AN
中科院分区：
文献类型：
--
作者：
Massi,M;Micossi,LG;deCaro,G;Epstein,AN
The tachykinins, eledoisin and physalaemin, given by intracerebroventricular (icv) injection have been shown to be potent antidipsogenic agents in rats. To evaluate their selectivity of action on rat ingestive behaviors, we compared their effects following icv injection on the intake of water, of milk containing 3.5 or 15% fat, and of solid food. The two tachykinins inhibited water intake induced by icv angiotensin II or by cellular dehydration, but did not reduce the intake of 15% fat milk or of solid food. The intake of 3.5% fat milk was inhibited only by the highest dose (1000 ng/rat) of eledoisin which also increased grooming and locomotion. The present findings suggest that in adult rats central eledoisin and physalaemin exert a selective suppressive effect on drinking behavior without affecting feeding.
