Toward the total synthesis of variecolin.
Toward the total synthesis of variecolin.
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DOI：
10.1021/ol015763l
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发表时间：
2001-06
期刊：
影响因子：
5.2
通讯作者：
G. Molander;Michael Quirmbach;L. Silva;Keith C. Spencer;J. Balsells
中科院分区：
文献类型：
--
作者：
G. Molander;Michael Quirmbach;L. Silva;Keith C. Spencer;J. Balsells
[反应：见正文]给出了一种全合成七萜类杂多可可林(1)的年化方法。利用碘化钐(II)的快速合成路线，在模型体系中合成了含有核心ABC环骨架的关键半缩醛。此外，还开发了用于全合成的组分片段的对映选择性合成。
[reaction: see text] An annulative approach toward the total synthesis of the sesterterpenoid variecolin (1) is presented. Synthesis of the key hemiketal, containing the core ABC ring skeleton, has been achieved on a model system by an expeditious route utilizing samarium(II) iodide. Furthermore, enantioselective syntheses of component fragments for the total synthesis have been developed.