Thank ORP9 for FFAT: With endosomal ORP10, it's fission accomplished!
Thank ORP9 for FFAT: With endosomal ORP10, it's fission accomplished!
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DOI:
10.1083/jcb.202112057
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发表时间:
2022-01-03
期刊:
影响因子:
--
通讯作者:
Eden ER
中科院分区:
文献类型:
--
作者:
Wong LH;Martello A;Eden ER
Wong et al. discuss recent work from Kawasaki et al. describing a role for lipid countertransport at ER–endosome contact sites in endosomal fission. Heterogeneity in endosomal membrane phospholipid content is emerging as a regulator of endocytic trafficking pathways. Kawasaki et al. (2021. J. Cell. Biol. https://doi.org/10.1083/jcb.202103141) demonstrate exchange of endosomal PI4P for PS by ORP10 at ER–endosome contact sites, with the consequent recruitment of endosomal fission factors.
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DOI:
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