The influence of CYP2R1 polymorphisms and gene-obesity interaction with hypertension risk in Chinese rural population
The influence of CYP2R1 polymorphisms and gene-obesity interaction with hypertension risk in Chinese rural population
复制标题
CYP2R1多态性和基因肥胖相互作用对中国农村人群高血压风险的影响
DOI：
10.1016/j.numecd.2021.11.003
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Wenjie Li
中科院分区：
文献类型：
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作者：
Ze Xu;Dongdong Zhang;Jiankui Lin;Xing Li;Yaping Liu;Jiaojiao Gao;Yuan Xue;Yujing Zhang;Runrong Ding;Guoyu Huang;Tong Zhao;Haoyue Huang;Chenxi Gu;Wenjie Li
背景和目的一些研究报道CYP 2 R1变异与高血压风险增加有关。然而，CYP 2 R1变异与环境因素在高血压易感性中的交互作用尚不清楚。因此，本研究评价了CYP 2 R1基因多态性对高血压易感性的影响，并探讨了CYP 2 R1基因多态性与肥胖对高血压易感性的交互作用。采用TaqMan探针法对CYP 2 R1基因的两个位点（rs 10766197和rs 12794714）进行基因分型。25-羟基维生素D的浓度由人酶联免疫吸附测定（ELISA）试剂盒测定。采用Logistic回归分析CYP 2 R1基因多态性与维生素D缺乏症（VDD）的关系。采用多因素降维法分析基因与环境的交互作用。采用多因素Logistic回归分析CYP 2 R1基因变异对高血压易感性的影响，以及CYP 2 R1基因变异与肥胖的交互作用。结果表明，rs 10766197（GG vs. AA）和rs 12794714（GGvs.AA）多态性均与VDD风险增加相关（OR = 1.49，95%CI = 1.08-2.05和OR = 1.63，95%CI = 1.19-2.25）。rs 12794714基因多态性在显性模型下与高血压的发病风险显著相关（OR = 1.26，95% CI = 1.01-1.56）。此外，rs 12794714与一般肥胖和肥胖症之间的相互作用（OR = 3.93，95%CI = 2.72-5.68）和向心性肥胖（OR = 3.22，95% CI = 2.29-4.52）结论CYP 2 R1变异与中国人群高血压易感性有关农村人口CYP 2 R1 rs 12794714与肥胖的交互作用可能增加高血压的风险。
Background and aimsSeveral studies have reported that variants inCYP2R1have been linked with an increased risk of hypertension. However, the interaction betweenCYP2R1variants and environmental factors on the susceptibility of hypertension remained unclear. Therefore, this study evaluated the influence ofCYP2R1polymorphisms on hypertension susceptibility, and explored the interaction effect ofCYP2R1variations and obesity on the disease.Methods and resultsWe included 766 incident hypertension cases matched with non-hypertension controls in a 1:1 ratio by sex, age (within 3 years). Two loci inCYP2R1gene (rs10766197 and rs12794714) were genotyped by TaqMan probe assays. The concentration of 25-hydroxyvitamin-D was determined by human enzyme-linked immunosorbent assay (ELISA) kits. The associations ofCYP2R1polymorphisms and risks of vitamin D deficiency (VDD) were analyzed by logistic regression. Multifactor dimensionality reduction (MDR) was used to analyze the gene–environment interaction. Multiple logistic regression was used to examine the effect ofCYP2R1gene variations, and the interaction betweenCYP2R1variation and obesity on hypertension susceptibility. The results showed that rs10766197 (GG vs. AA) and rs12794714 (GGvs.AA) polymorphisms were both associated with an increased risk of VDD (OR = 1.49, 95% confidence interval (CI) = 1.08–2.05 and OR = 1.63, 95% CI = 1.19–2.25, respectively), after adjustment for potential risk factors. We also found that rs12794714 polymorphism was significantly associated with elevated risk of hypertension under the dominant model (OR = 1.26, 95% CI = 1.01–1.56). In addition, the interactions between rs12794714 with both general obesity (OR = 3.93, 95% CI = 2.72–5.68) and central obesity (OR = 3.22, 95% CI = 2.29–4.52) have significant effects on hypertension susceptibility.ConclusionsThe study provided further evidence thatCYP2R1variation was associated with a higher risk of hypertension in Chinese rural population. The interaction betweenCYP2R1rs12794714 and obesity may increase the risk of hypertension.