Reduced isotope dose with rapid SPECT MPI imaging: Initial experience with a CZT SPECT camera
Reduced isotope dose with rapid SPECT MPI imaging: Initial experience with a CZT SPECT camera
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DOI：
10.1007/s12350-010-9215-5
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发表时间：
2010-12-01
影响因子：
2.4
通讯作者：
Henzlova, Milena J.
中科院分区：
文献类型：
--
作者：
Duvall, W. Lane;Croft, Lori B.;Henzlova, Milena J.
心脏SPECT成像需要变得更短，使用更低的辐射剂量，以与其他可用的无创成像方式竞争。最近推出的碲化镉锌（CZT） SPECT相机有可能实现这两个目标，但迄今为止临床经验有限。所有患者在4个月内使用CZT相机（Discovery NM 530c）进行应激性MPI的图像进行了回顾。患者根据影像学方案分为三组：仅低剂量应激、仅高剂量应激和标准剂量休息应激。低剂量应激患者按性别、应激源和BMI与高剂量应激和休息应激受试者相匹配。对成像方案不知情的读者将应力图像质量按4分制进行评分。记录人口统计学、示踪剂剂量、应激成像时间和总计数。717例影像学患者，平均年龄64.0岁，50.5%为女性，58.9%有运动应激，平均BMI为27.9 kg/m(2)。103名低剂量应激患者与对照组相匹配。在低剂量应激患者中成像5分钟，在高剂量应激和休息应激患者中成像3分钟，结果总计数相似。这在三组中产生了相似的图像质量，与高剂量应激组相比，低剂量应激组的同位素剂量减少了57%。新的SPECT CZT相机技术可以显着减少辐射暴露和采集时间，而不会损失图像质量。
Cardiac SPECT imaging needs to become shorter and use lower radiation doses to compete with other available noninvasive imaging modalities. Recently introduced cadmium zinc telluride (CZT) SPECT cameras have the potential to achieve both goals, but clinical experience is so far limited.Images of all patients undergoing a stress MPI over a 4-month period using a CZT camera (Discovery NM 530c) were reviewed. Patients were divided into three groups based on imaging protocols: low-dose stress-only, high-dose stress-only, and standard dose rest-stress. Low-dose stress-only patients were matched by gender, stressor, and BMI to high-dose stress-only and rest-stress subjects. Stress image quality was graded on a four-point scale by readers blinded to the imaging protocol. Demographics, tracer dose, stress imaging time, and total counts were recorded.Of 717 patients imaged, the mean age was 64.0 years, 50.5% were female, 58.9% underwent exercise stress, and the average BMI was 27.9 kg/m(2). A total of 103 low-dose stress-only patients were matched to controls. Imaging for 5 minutes in low-dose stress-only patients and for 3 minutes in high-dose stress-only and rest-stress patients, resulted in a similar number of total counts. This produced similar image quality in the three groups with a 57% isotope dose reduction in the low-dose stress-only compared to the high-dose stress-only group.New SPECT CZT camera technology allows significantly reduced radiation exposure and acquisition time without loss of image quality.