Pathways to Melanoma
Pathways to Melanoma
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DOI：
10.1016/j.sder.2010.10.004
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发表时间：
2010-12-01
影响因子：
--
通讯作者：
Tsao, Hensin
中科院分区：
文献类型：
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作者：
Ko, Justin M.;Velez, Nicole F.;Tsao, Hensin
黑色素瘤是最具侵袭性的人类恶性肿瘤之一，但人们对其了解甚少。基因组学的进步使人们对这种疾病有了更细致的了解，超越了传统的发育不良痣到黑色素瘤模型，并确定了导致黑色素瘤的多种不同致癌途径。对黑色素瘤分子机制的了解为靶向治疗方法的开发打开了大门。随着我们进入个性化医疗时代，临床医生必须了解并能够确定患者黑色素瘤的分子特征，因为该特征将指导风险分层，遗传咨询和治疗定制。本文综述了黑色素瘤发展的不同途径，特别强调了最近发现的突变及其对患者护理的影响。Semin Cutan Med Surg 29：210-217（C）2010由Elsevier Inc.出版。
Melanoma is one of the most aggressive and yet poorly understood of human malignancies. Advances in genomics has allowed a more nuanced understanding of the disease, moving beyond the traditional dysplastic nevus-to-melanoma model and identifying multiple divergent oncogenic pathways leading to melanoma. An understanding of the molecular mechanisms driving melanoma has opened the doors for the development of targeted therapeutic approaches. As we enter the era of personalized medicine, it will be critical for clinicians to both appreciate and be able to determine the molecular profile of their patients' melanoma because this profile will guide risk stratification, genetic counseling, and treatment customization. A review of the divergent pathways of melanoma development is presented here, with a particular emphasis on recently identified mutations, and their implications for patient care. Semin Cutan Med Surg 29:210-217 (C) 2010 Published by Elsevier Inc.