Association among serum cortisol, dehydroepiandrosterone-sulfate levels and psychiatric symptoms in men with chronic schizophrenia
Association among serum cortisol, dehydroepiandrosterone-sulfate levels and psychiatric symptoms in men with chronic schizophrenia
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DOI：
10.1016/j.comppsych.2017.03.011
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发表时间：
2017-07-01
影响因子：
7.3
通讯作者：
Li, Yan
中科院分区：
文献类型：
--
作者：
Peng, Rui;Li, Yan
目的：本研究的目的是探讨慢性精神分裂症男性患者血清皮质醇和硫酸脱氢表雄酮（DHEA-S）水平与精神症状的可能关系。这项回顾性研究涉及162名男性精神分裂症患者和138名年龄匹配的健康对照者，收集了他们的人口统计学特征、发病年龄、病程、阳性和阴性综合征量表（PANSS）评分和非典型抗精神病药物治疗史。计算血清皮质醇和DHEA-S水平，以及两种水平的比值。结果：精神分裂症患者血清皮质醇、DHEA-S水平及皮质醇/DHEA-S比值均高于对照组（P < 0.01）。在患者中，治疗后血清皮质醇和DHEA-S水平显著低于治疗前（p < 0.01），尽管皮质醇与DHEA-S水平的比值保持相似。血清皮质醇、DHEA-S水平及其比值与PANSS阴性症状评分呈正相关。结论：精神分裂症的病理生理过程可能与皮质醇、DHEA-S的扩散水平有关。这些水平可以作为诊断精神分裂症和监测治疗效果的生物标志物。(C)2017爱思唯尔公司All rights reserved.
Purpose: The purpose of this study was to examine possible associations of serum levels of cortisol and dehydroepiandrosterone-sulfate (DHEA-S) with psychiatric symptoms in men with chronic schizophrenia.Methods: This retrospective study involved 162 men with schizophrenia and 138 age-matched healthy controls, for whom data were collected on demographic characteristics, age at disease onset, disease duration, positive and negative syndrome scale (PANSS) scores, and history of atypical antipsychotic treatment. Serum levels of cortisol and DHEA-S were calculated, as well as the ratios of the two levels. Possible correlations were explored between these levels and psychiatric symptoms before and after antipsychotic treatment.Results: Serum levels of cortisol and DHEA-S levels as well as the ratios of cortisol to DHEA-S levels were higher in patients than in controls (p < 0.01). Among patients, serum levels of cortisol and DHEA-S were significantly lower after treatment than before (p < 0.01), although the ratios of cortisol to DHEA-S levels remained similar. Serum levels of cortisol, DHEA-S and the ratios of the two levels were positively correlated with the negative symptoms score on the PANSS.Conclusions: The pathophysiology of schizophrenia may involve in the spread levels of cortisol and DHEA-S. These levels may serve as biomarkers for diagnosing schizophrenia and monitoring treatment efficacy. (C) 2017 Elsevier Inc. All rights reserved.