Numeric modeling of the cardiovascular system with a left ventricular assist device.
Numeric modeling of the cardiovascular system with a left ventricular assist device.
复制标题
使用左心室辅助装置对心血管系统进行数字建模。
DOI：
10.1097/00002480-199901000-00019
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Thomas,JD
中科院分区：
文献类型：
--
作者：
Zhou,J;Armstrong,GP;Medvedev,AL;Smith,WA;Golding,LA;Thomas,JD
本文描述了一个由肿块参数心血管系统 (CVS) 模型和克利夫兰诊所植入式心室辅助系统 (IVAS) 模型组成的数值模型，IVAS 是一种非搏动旋转泵，旨在增强衰竭的左心室。本研究的目的是1）观察以不同速度运行的各种生理和病理生理条件下CVS和IVAS之间的血流动力学相互作用； 2) 允许测试和优化各种 IVAS 控制算法。现有的 CVS 数值模型（24 个耦合微分方程，代表所有心室以及全身和肺脉管系统）经过修改，添加 IVAS 泵作为左心室和主动脉之间的辅助室，具有来自体外测试的压力-流速特征。对不同运动水平下泵以不同速度运行时具有正常和异常收缩和舒张功能障碍的心室进行了模拟。计算机模拟表明：1）数值建模可用于预测各种情况下 CVS 对 IVAS 的血流动力学反应； 2) IVAS 可使心输出量正常化，尤其是在心力衰竭的情况下，尽管脉压降低； 3）可以根据模拟研究开发各种控制算法，使 IVAS 适应 CVS 的生理需求。 ASAIO杂志1999； 45：83-89。
A numeric model consisting of a lump-parameter cardiovascular system (CVS) model and a model for the Cleveland Clinic Implantable Ventricular Assist System (IVAS), a nonpulsatile rotary pump designed to augment the failing left ventricle, are described in this paper. The purposes of this study were to 1) observe the hemodynamic interactions between CVS and IVAS under various physiologic and pathophysiologic conditions running at different speeds; and 2) allow testing and optimization of various IVAS control algorithms. An existing numeric model of CVS (24 coupled differential equations, representing all cardiac chambers and systemic and pulmonary vasculature) was modified to add the IVAS pump as an auxiliary chamber between the left ventricle and aorta with pressure-flow-speed characteristics derived from in vitro testing. Simulations were conducted for ventricles with normal and abnormal systolic and diastolic dysfunction at different exercise levels with the pump running at various speeds. Computer simulations show that 1) numeric modeling is useful for predicting hemodynamic response of CVS to IVAS in various circumstances; 2) IVAS results in normalization of cardiac output, especially in failing hearts, although with reduced pulse pressure; and 3) various control algorithms allowing adaptation of IVAS to physiologic demands of CVS could be developed based on the simulation study. ASAIO Journal 1999; 45: 83–89.