Biological performance of tantalum
Biological performance of tantalum
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DOI：
10.1016/0267-6605(94)90113-9
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发表时间：
1994-01-01
期刊：
影响因子：
--
通讯作者：
Black, Jonathan
中科院分区：
文献类型：
--
作者：
Black, Jonathan
进行了详细的文献检索，以确定目前关于钽的生物性能的知识。纯金属似乎在很大程度上在体内和体外都是惰性的。纯金属及其主要氧化物都具有低溶解度和毒性；然而，卤化物更具有生物活性。局部宿主反应是良性的，其特征是软组织的重要包封和硬组织中频繁的骨整合，使人联想到钛。自1940年以前，钽就已经在临床使用，并发现了广泛的诊断和植入应用，显然总体效果很好。在某些应用中，例如放射学骨标记和颅闭合，钽可能是当前的首选材料。综上所述，金属钽是一种很有前途的生物材料，其应用受到技术而非生物性能考虑的限制。
A detailed literature search was carried out to define the current knowledge about the biological performance of tantalum. The pure metal appears, to a great degree, to be inert both in vivo and in vitro. Both the pure metal and its principle oxide possess low solubility and toxicity; however, halide compounds are more biologically active. Local host response is benign, characterized by vital encapsulation in soft tissue and frequent osteointegration, reminiscent of titanium, in hard tissue. Tantalum has been in clinical use since before 1940 and has found a wide range of diagnostic and implant applications, with apparently overall excellent results. In some applications, such as for radiographic bone markers and cranial closure, tantalum may well be the current material of choice. In summary, metallic tantalum is a promising biomaterial whose applications have been limited by technical rather than biological performance considerations.