A feasibility study of optical coherence tomography for guiding deep brain probes
A feasibility study of optical coherence tomography for guiding deep brain probes
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DOI：
10.1016/j.jneumeth.2005.12.008
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发表时间：
2006-06-30
影响因子：
3
通讯作者：
Rezai, Ali R.
中科院分区：
文献类型：
--
作者：
Jeon, Sung W.;Shure, Mark A.;Rezai, Ali R.
脑深部电刺激（DBS）是治疗帕金森病和特发性震颤等多种疾病的有效方法。然而，解剖定位结合该区域的微电极标测需要大量的手术时间。此外，如果轨迹与皮质下血管相交，细尖端微电极会带来出血风险。为了减少手术时间和出血风险，我们建议使用光学相干断层扫描（OCT）来引导DBS探头的插入。我们在大鼠脑中进行了体外实验，以研究这种应用的可行性。结果表明，OCT能够区分大鼠脑内的结构。与灰质相比，白色物质倾向于具有更高的峰值反射率和更陡的衰减率。该结构信息可帮助指导DBS探头推进和电气测量。(c)2005 Elsevier B.V.保留所有权利。
Deep brain simulation (DBS) is effective for the treatment of various diseases including Parkinson's disease and essential tremor. However, anatomical targeting combined with microelectrode mapping of the region requires significant surgical time. Also, the fine-tipped microelectrode imposes a risk of hemorrhage in the event that the trajectory intersects subcortical vessels. To reduce the operation time and the risk of hemorrhage, we propose to use optical coherence tomography (OCT) to guide the insertion of the DBS probe. We conducted in vitro experiments in the rat brain to study the feasibility of this application. The result shows that OCT is able to differentiate structures in the rat brain. White matter tends to have higher peak reflectivity and steeper attenuation rate compared to gray matter. This structural information may help guide DBS probe advance and electrical measurements. (c) 2005 Elsevier B.V. All rights reserved.