Recent advances in understanding the role of phasic dopamine activity
Recent advances in understanding the role of phasic dopamine activity
复制标题
DOI：
10.12688/f1000research.19793.1
复制
发表时间：
2019-09
期刊：
影响因子：
--
通讯作者：
W. Schultz
中科院分区：
文献类型：
--
作者：
W. Schultz
最新的动物神经生理学研究表明，除了行为学习之外，多巴胺奖励预测误差信号还驱动神经元学习，并反映了显式偶然性之外的主观奖励表征。信号符合正式的经济概念和功能，在现实世界中的消费者选择和社会互动。早期反应成分受物理影响，奖励环境和新奇的影响，但不能完全编码预测错误。有些多巴胺神经元被厌恶性刺激激活，这可能反映了物理刺激的影响或真正的厌恶性，但它们似乎不编码一般的负值或厌恶性预测错误。奖励预测误差信号由不同的、异质的、较小的和较慢的变化补充，这些变化反映了对行为激活的感觉和运动贡献者，例如实质性运动（与精确的运动控制相反）、奖励期望、空间选择、活力和动机。不同的多巴胺信号似乎违背了一个简单的统一概念，应该加以区分，以更好地理解阶段性多巴胺功能。
The latest animal neurophysiology has revealed that the dopamine reward prediction error signal drives neuronal learning in addition to behavioral learning and reflects subjective reward representations beyond explicit contingency. The signal complies with formal economic concepts and functions in real-world consumer choice and social interaction. An early response component is influenced by physical impact, reward environment, and novelty but does not fully code prediction error. Some dopamine neurons are activated by aversive stimuli, which may reflect physical stimulus impact or true aversiveness, but they do not seem to code general negative value or aversive prediction error. The reward prediction error signal is complemented by distinct, heterogeneous, smaller and slower changes reflecting sensory and motor contributors to behavioral activation, such as substantial movement (as opposed to precise motor control), reward expectation, spatial choice, vigor, and motivation. The different dopamine signals seem to defy a simple unifying concept and should be distinguished to better understand phasic dopamine functions.