Outcome of patients with hemoglobinopathies given either cord blood or bone marrow transplantation from an HLA-identical sibling
Outcome of patients with hemoglobinopathies given either cord blood or bone marrow transplantation from an HLA-identical sibling
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DOI：
10.1182/blood-2013-03-489112
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发表时间：
2013-08-08
期刊：
影响因子：
20.3
通讯作者：
Rocha, Vanderson
中科院分区：
文献类型：
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作者：
Locatelli, Franco;Kabbara, Nabil;Rocha, Vanderson
我们分析了485名接受HLA相同同胞脐带血移植（CBT，n=96）或骨髓移植（BMT，n=389）的重型地中海贫血（TM）或镰状细胞病（SCD）患者的结局。与接受骨髓移植的患者相比，接受CBT的患者明显更年轻（中位年龄6岁vs 8岁，P= 0.02），接受治疗的时间更近（中位年龄2001年vs 1999年，P
We analyzed the outcomes of 485 patients with thalassemia major (TM) or sickle cell disease (SCD) receiving HLA-identical sibling cord blood transplantation (CBT, n=96) or bone marrow transplantation (BMT, n=389). Compared with patients given BMT, CBT recipients were significantly younger (median age 6 vs 8 years, P=.02), and were treated more recently (median year 2001 vs 1999, P