Paternal transmission of complex phenotypes in inbred mice.
Paternal transmission of complex phenotypes in inbred mice.
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DOI：
10.1016/j.biopsych.2009.05.026
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发表时间：
2009-12-01
影响因子：
10.6
通讯作者：
Hen R
中科院分区：
文献类型：
--
作者：
Alter MD;Gilani AI;Champagne FA;Curley JP;Turner JB;Hen R
近亲交配的小鼠在基因上是相同的，但在复杂的行为上表现出很大的变异性，比如在新环境中的活动水平。这种变异性与发育早期经历的父母照顾水平有关。尽管双亲和单亲品系的母系效应已有报道，但尚未对非双亲品系的父系效应进行调查，在非双亲品系中，后代完全由母亲抚养。在单亲近交系Balb/CJ小鼠品系中，我们研究了父亲的开阔场地活动与雄性和雌性后代在开阔场地活动的关系。研究了潜在的父系行为传递中介因素，包括母体照料、生长参数、产仔特征以及父亲产前陪伴怀孕母亲的时间。父亲的空地活动与雌性后代的空地活动有关，但与雄性后代的空地活动无关。母亲产后护理的变化与雌性后代在野外的活动有关，但与雄性后代在野外的活动无关，但不会中介父亲对后代行为的影响。父亲对后代生长参数的影响是存在的，但这些影响也不能中介父亲对行为的影响。在仅由母亲饲养的遗传相同的小鼠中，复杂特征的父系传递表明了一种潜在地由表观遗传因素介导的非遗传遗传机制。排除多种父性效应对后代的影响，表明近交系小鼠通过复杂表型的精子进行生殖系父系遗传的可能性。需要进一步的研究来检验这些有趣的可能性。
Inbred mice are genetically identical but nonetheless demonstrate substantial variability in complex behaviors such as activity levels in a novel environment. This variability has been associated with levels of parental care experienced early in development. Although maternal effects have been reported in biparental and uniparental strains, there have been no investigations of paternal effects in non-biparental strains in which offspring are reared exclusively by mothers. In the uniparental inbred Balb/cJ mouse strain, we examined the relationship of paternal open-field activity to the activity of both male and female offspring in the open-field. Potential mediators of paternal transmission of behavior were examined, including maternal care, growth parameters, litter characteristics, and time the father was present with the pregnant mother prenatally. An association of paternal open-field activity with the open-field activity of female but not male offspring was found. Variation in maternal postnatal care was associated with female but not male offspring activity in the open-field but did not mediate paternal effects on offspring behavior. Paternal effects on offspring growth parameters were present, but these effects also did not mediate paternal effects on behavior. Paternal transmission of complex traits in genetically identical mice reared only by mothers suggests a nongenetic mechanism of inheritance potentially mediated by epigenetic factors. The exclusion of multiple mediators of paternal effects on offspring suggests the possibility of germline paternal inheritance via sperm of complex phenotypes in inbred mice. Future studies are required to examine these interesting possibilities.