Involvement of the female genital tract in pemphigus vulgaris
Involvement of the female genital tract in pemphigus vulgaris
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DOI：
10.1097/01.aog.0000185258.74177.91
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发表时间：
2005-11-01
影响因子：
7.2
通讯作者：
Ahmed, AR
中科院分区：
文献类型：
--
作者：
Malik, M;Ahmed, AR
背景：寻常型天疱疮女性生殖道受累的报道很少。我们报告了 34 例外阴、阴道或两者均受累的寻常型天疱疮患者。 方法：我们回顾了 1988 年 7 月至 2005 年 6 月在三级皮肤科转诊中心接受治疗的 34 名女性的临床数据。 结果：在 34 名患者中，21 例有阴唇受累，3 例有阴道受累，10 例同时有阴唇和阴道受累。寻常型天疱疮的平均发病年龄为 49 岁。所有患者的多个其他部位都有寻常型天疱疮受累，并且所有患者都有其他粘膜受累，最常见的是口腔（97%）。生殖器寻常型天疱疮复发率为 35%，平均复发 6 次（范围 1-11）。所有患者的寻常型天疱疮均通过全身和局部治疗得到控制。平均76个月（范围9-204）的长期随访表明，没有因生殖器受累而出现长期后遗症。结论：寻常型天疱疮累及女性生殖道的情况很少见。外阴病变比阴道病变更常见。通过适当的局部和全身治疗，患者可以完全康复，不会留下后遗症。
BACKGROUND: involvement of the genital tract in women with pemphigus vulgaris has rarely been reported. We report 34 patients with pemphigus vulgaris who have involvement of the vulva, vagina, or both.METHODS: We reviewed the clinical data on 34 women treated at a tertiary dermatology referral center from July 1988 to June 2005.RESULTS: Of 34 patients, 21 had labial involvement, 3 had vaginal involvement, and 10 had both labial and vaginal involvement. The mean age of onset of pemphigus vulgaris was 49 years. All patients had pemphigus vulgaris involvement at multiple other sites, and all had other mucous membrane involvement, most commonly oral (97%). Recurrent episodes of genital pemphigus vulgaris were noted in 35%, with a mean of 6 recurrences (range 1-11). In all the patients the pemphigus vulgaris was controlled with systemic and local therapy. Longterm follow-up for a mean of 76 months (range 9-204) indicated that no long-term sequela occurred due to genital involvement.CONCLUSION: Involvement of the female genital tract in pemphigus vulgaris is rare. Vulvar lesions occur more commonly than vaginal lesions. With appropriate topical and systemic therapy, patients can have full recovery with no sequelae.