Elevated serum levels of TNF soluble receptors in patients with positive anti-neutrophil cytoplasmic antibodies.
Elevated serum levels of TNF soluble receptors in patients with positive anti-neutrophil cytoplasmic antibodies.
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抗中性粒细胞胞浆抗体阳性的患者血清 TNF 可溶性受体水平升高。
DOI：
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
J. Dayer
中科院分区：
文献类型：
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作者：
P. Roux‐Lombard;H.;J. Peter;J. Dayer
ANCA 存在于各种系统性血管炎中，并被认为与细胞因子等其他因素协同作用，在疾病的发病机制中发挥作用。总共分析了 36 份 ANCA 阳性和 10 份 ANCA 阴性血清样本中是否存在 TNF 可溶性受体 (TNF-sR)，这些受体从激活的细胞表面脱落，可能充当 TNF 抑制剂。与 ANCA 阴性样本相比，ANCA 阳性样本中 67% 的 TNF-sR75 升高，72% 的 TNF-sR55 升高（平均 [S.E.] 18.7 [17.3] vs 3.6 [1.5] 和 10.5 [9.7] vs 1.9 [0.7] ng/ml，P < 0.01）。 ANCA 患者 TNF-sR 升高表明细胞因子及其抑制剂参与 ANCA 相关自身免疫性疾病的发病机制。
ANCA are found in various systemic vasculitis and are supposed to play a role in the pathogenesis of the disease, in co-operation with other factors such as cytokines. A total of 36 ANCA-positive and 10 ANCA-negative serum samples were analysed for the presence of TNF soluble receptors (TNF-sR), which are shed from the surface of activated cells and may act as TNF inhibitors. Of the ANCA-positive samples, 67% had elevated TNF-sR75 and 72% had elevated TNF-sR55 compared to ANCA-negative specimens (mean [S.E.] 18.7 [17.3] vs 3.6 [1.5] and 10.5 [9.7] vs 1.9 [0.7] ng/ml, P < 0.01). Elevation of TNF-sR in patients with ANCA suggests that cytokines and their inhibitors are involved in the pathogenesis of ANCA-associated autoimmune diseases.
人中性粒细胞弹性蛋白酶从 75 kDa 肿瘤坏死因子 (TNF) 受体中释放配体结合片段。
DOI：
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发表时间：
1991
期刊：
The Journal of biological chemistry
影响因子：
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作者：
Porteu,F;Brockhaus,M;Wallach,D;Engelmann,H;Nathan,CF
通讯作者：
Nathan,CF