TIME COURSE OF MUSCULAR-ATROPHY DURING IMMOBILIZATION OF HINDLIMBS IN RATS
TIME COURSE OF MUSCULAR-ATROPHY DURING IMMOBILIZATION OF HINDLIMBS IN RATS
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DOI：
10.1152/jappl.1977.43.4.656
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发表时间：
1977-01-01
影响因子：
3.3
通讯作者：
BOOTH, FW
中科院分区：
文献类型：
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作者：
BOOTH, FW
在石膏猫中，将大鼠的后肢固定不同的持续时间，并测定肌肉萎缩和这些肌肉中所选蛋白质的时程。在这些肌肉的长度小于静止长度在固定过程中，指数衰减到一个新的明显的稳定状态后，萎缩的湿和干肌肉重量和缩二脲蛋白，细胞色素c，柠檬酸合酶的量。上述参数呈指数衰减，在新的表观稳态水平下，下降至最终下降的一半所需的时间约为4-6天。肌红蛋白[Mb]浓度在萎缩过程中增加，Mb的量在萎缩过程中保持不变。当四肢的固定程序是这样的，肌肉拉伸的长度大于休息长度，然后发生萎缩延迟;事实上，在某些情况下，肌肉肥大时，固定在拉伸位置。
The hindlimbs of rats were immobilized, in plaster cats, for varying durations and the time course for atrophy of muscle and of selected proteins in these muscles were determined. In those muscles whose lengths were at less than resting length during the fixation procedures, exponential decay to a new apparent steady state after atrophy was shown by wet and dry muscle weights and by the amounts of biuret protein, cytochrome c, and citrate synthase. The time taken to decrease to one-half of the final decrease at the new apparent steady state level was about 4-6 days for the above parameters which decayed exponentially. The myoglobin [Mb] concentration increased during atrophy and the amount of Mb remained unchanged during atrophy. When fixation procedures on limbs were such that muscles were stretched to lengths greater than reasting length, then the onset of atrophy was delayed; indeed, in some cases muscles hypertrophied when fixed in the stretched position.