Temperature sensing by an olfactory neuron in a circuit controlling behavior of C-elegans
Temperature sensing by an olfactory neuron in a circuit controlling behavior of C-elegans
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DOI：
10.1126/science.1148922
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发表时间：
2008-05-09
期刊：
影响因子：
56.9
通讯作者：
Mori, Ikue
中科院分区：
文献类型：
--
作者：
Kuhara, Atsushi;Okumura, Masatoshi;Mori, Ikue
温度是一个不可避免的环境因素，影响着地球上任何生物的新陈代谢和行为，然而人们对动物如何感知温度知之甚少。秀丽隐杆线虫“记忆”温度，这种存储的信息改变了它随后沿着温度梯度的迁移。我们发现嗅觉神经元AWC可以感知温度。钙成像显示AWC对温度变化有反应，反应阈值取决于动物先前暴露的温度。在异三聚体鸟嘌呤核苷酸结合蛋白（G蛋白）介导的信号通路受损的突变体中，AWC对温度有高反应，而AIY中间神经元（对AWC是突触后的）对温度有低反应。因此，温度感觉对控制记忆调节行为的神经回路表现出强大的影响。
Temperature is an unavoidable environmental cue that affects the metabolism and behavior of any creature on Earth, yet how animals perceive temperature is poorly understood. The nematode Caenorhabditis elegans "memorizes" temperatures, and this stored information modifies its subsequent migration along a temperature gradient. We show that the olfactory neuron designated AWC senses temperature. Calcium imaging revealed that AWC responds to temperature changes and that response thresholds differ depending on the temperature to which the animal was previously exposed. In the mutant with impaired heterotrimeric guanine nucleotide- binding protein ( G protein)- mediated signaling, AWC was hyperresponsive to temperature, whereas the AIY interneuron ( which is postsynaptic to AWC) was hyporesponsive to temperature. Thus, temperature sensation exhibits a robust influence on a neural circuit controlling a memory- regulated behavior.