Insect resistance management in GM crops: past, present and future
Insect resistance management in GM crops: past, present and future
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DOI：
10.1038/nbt1056
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发表时间：
2005-01-01
影响因子：
46.9
通讯作者：
Shelton, AM
中科院分区：
文献类型：
--
作者：
Bates, SL;Zhao, JZ;Shelton, AM
表达来自苏云金杆菌（Bt）的杀虫蛋白的转基因植物于1996年首次商业化，当时一些科学家、监管机构和环保人士担心，广泛使用苏云金杆菌作物将不可避免地导致抗性和“公共产品”的损失，特别是害虫对苏云金杆菌蛋白的敏感性。八年后，Bt玉米和棉花在全球累计种植面积超过8000万公顷。尽管有相反的可怕预测，但对Bt作物的抗性尚未记录在案，这表明抗性管理策略迄今为止是有效的。然而，目前延缓耐药性的战略仍远非理想。八年无抗药性为研究人员、监管机构和产业界提供了一个及时的机会，重新评估抗药性的风险，以及保护Bt和其他新型抗虫作物的最有效策略。
Transgenic plants expressing insecticidal proteins from the bacterium Bacillus thuringiensis (Bt) were first commercialized in 1996 amid concern from some scientists, regulators and environmentalists that the widespread use of Bt crops would inevitably lead to resistance and the loss of a 'public good,' specifically, the susceptibility of insect pests to Bt proteins. Eight years later, Bt corn and cotton have been grown on a cumulative area >80 million ha worldwide. Despite dire predictions to the contrary, resistance to a Bt crop has yet to be documented, suggesting that resistance management strategies have been effective thus far. However, current strategies to delay resistance remain far from ideal. Eight years without resistance provides a timely opportunity for researchers, regulators and industry to reassess the risk of resistance and the most effective strategies to preserve Bt and other novel insect-resistant crops in development.