COMBINED THERAPY OF MITOMYCIN-C AND CHINESE MEDICAL HERBS ON EXPERIMENTAL LIVER-CANCER
COMBINED THERAPY OF MITOMYCIN-C AND CHINESE MEDICAL HERBS ON EXPERIMENTAL LIVER-CANCER
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DOI：
10.1142/s0192415x93000078
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发表时间：
1993-01-01
影响因子：
5.7
通讯作者：
YOU, JS
中科院分区：
文献类型：
--
作者：
HAU, DM;CHEN, TH;YOU, JS
本研究选用ICR雄性小鼠肝内植入肉瘤180个肿瘤细胞（1 × 10(7)）。植入24小时后随机分为各组。其中1组为肿瘤对照组，其余组分别单独或联合应用丝裂霉素C （MMC）和石川大补汤（SCTPT）或石鸿一号（SHO）。结果显示，肿瘤对照组的死亡率（MR60）为100%，平均生存时间（MST60）为21.11±10.69 d。MMC与SHO联合治疗组疗效最佳，mr60为55.0%，MST 60为47.0±13.4天。
In this research, ICR male mice were chosen for intrahepatic implantation of sarcoma 180 tumor cells (1 x 10(7)). The mice were randomly divided into various groups 24 hours after implantation. One of the groups was the tumor control, the others were singly or combinedly treated with mitomycin C (MMC) and Shih Chuan-Ta-Pu-Tang (SCTPT) or Shi-Hung-One (SHO). The results revealed that the mortality rate (MR60) in the tumor control was 100% and the mean survival time (MST60) was 21.11 +/- 10.69 days. The best therapeutic effect appeared in the group treated with the combination of MMC and SHO, its MR6o was 55.0% and MST 60 was 47.0 +/- 13.4 days.