Lipid-lowering efficacy of hesperetin metabolites in high-cholesterol fed rats
Lipid-lowering efficacy of hesperetin metabolites in high-cholesterol fed rats
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DOI：
10.1016/s0009-8981(02)00344-3
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发表时间：
2003-01-01
影响因子：
5
通讯作者：
Choi, MS
中科院分区：
文献类型：
--
作者：
Kim, HK;Jeong, TS;Choi, MS
背景：橙皮素是一种天然存在的具有降血脂特性的类黄酮。
方法：雄性大鼠喂食含1克/100克高胆固醇的饲料5周，同时给予橙皮素（0.02%，0.066毫摩尔/100克饲料）和橙皮素代谢物。橙皮素的代谢物间羟基肉桂酸（m - HC）、3,4 - 二羟基苯丙酸（3,4 - DHPP）和3 - 甲氧基 - 4 - 羟基肉桂酸（阿魏酸）按照与橙皮素等量进行补充。
结果：与对照组相比，补充橙皮素及其代谢物显著降低了血浆总胆固醇和甘油三酯浓度。补充橙皮素及其代谢物的组肝脏中的HMG - CoA还原酶和酰基辅酶A：胆固醇酰基转移酶（ACAT）活性显著低于对照组。补充橙皮素、m - HC、3,4 - DHPP和阿魏酸的组酸性固醇的排泄量显著高于对照组。
结论：这些结果表明，橙皮素代谢物在体内降低血浆脂质活性方面与橙皮素起着同样有效的作用，并且进一步表明，如HMG - CoA还原酶和ACAT活性降低所显示的，橙皮素及其代谢物同时降低了胆固醇的生物合成和酯化（酯化可能是esterification误写，此处应为“酯化（酯化作用）”）。（C）2002爱思唯尔科学出版社。保留所有权利。
Background: Hesperetin is a naturally occurring flavonoid that has hypolipidemic properties. Methods: Male rats were fed a 1 g/100 g high-cholesterol diet for 5 weeks along with hesperetin (0.02%, 0.066 mmol/100 g diet) and hesperetin metabolites. The hesperetin metabolites, m-hydroxycinnamic acid (m-HC), 3,4-dihydroxyphenylpropionic acid (3,4-DHPP), and 3-methoxy-4-hydroxycinnamic acid (ferulic acid), were supplemented based on an equivalent amount of hesperetin. Results: The supplementation of hesperetin and its metabolites significantly lowered the plasma total cholesterol and triglyceride concentrations compared to the control group. The hepatic HMG-CoA reductase and acyl-CoA: cholesterol acyltransferase (ACAT) activities were significantly lower in the hesperetin and its metabolite supplemented groups than in the control group. The excretion of acidic sterol was significantly higher in the hesperetin, m-HC, 3,4-DHPP, and ferulic acid supplemented groups than in the control group. Conclusions: These results demonstrated that the hesperetin metabolites played as potent a role as hesperetin in plasma lipid-lowering activities in vivo, and further suggest that cholesterol biosynthesis and esterification were concomitantly reduced by hesperetin and its metabolites, as indicated by the decreased HMG-CoA reductase and ACAT activities. (C) 2002 Elsevier Science B.V. All rights reserved.