m(6)A Regulator Expression Segregates Meningiomas Into Biologically Distinct Subtypes.
m(6)A Regulator Expression Segregates Meningiomas Into Biologically Distinct Subtypes.
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DOI：
10.3389/fonc.2021.760892
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发表时间：
2021
影响因子：
4.7
通讯作者：
Gong Y
中科院分区：
文献类型：
--
作者：
Chen J;Sun S;Ren L;Hua L;Wang D;Xie Q;Wirsching HG;Deng J;Weller M;Gong Y
Meningiomas are the most common primary intracranial tumors in adults. According to the 2021 World Health Organization (WHO) classification of central nervous system tumors, approximately 80% of meningiomas are WHO grade 1, that is, histopathologically benign, whereas about 20% are WHO grade 2 or grade 3, showing signs of atypia or malignancy. The dysregulation of N6-methylation (m6A) regulators is associated with disorders of diverse critical biological processes in human cancer. This study aimed to explore whether m6A regulator expression was associated with meningioma molecular subtypes and immune infiltration. We evaluated the m6A modification patterns of 160 meningioma samples based on 19 m6A regulators and correlated them with immune infiltration characteristics. Novel molecular subtypes were defined based on prognostic hub gene expression. Two meningioma clusters were identified based on the expression of 19 m6A regulators. In cluster 1, 607 differentially expressed genes (DEGs) were upregulated and 519 were downregulated. A total of 1,126 DEGs comprised three gene expression modules characterized by turquoise, blue, and gray. Functional annotation suggested that the turquoise module was involved in Wnt-related and other important cancer-related pathways. We identified 32 hub genes in this module by constructing a protein–protein interaction network. The meningioma samples were divided into two molecular subtypes. EPN1, EXOSC4, H2AX, and MZT2B not only showed significant differences between meningioma molecular subtypes but also had the potential to be the marker genes of specific meningioma subtypes. m6A regulator gene expression may be a novel prognostic marker in meningioma.
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DOI：
10.1093/bioinformatics/bts251
发表时间：
2012-07-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Jiao X;Sherman BT;Huang da W;Stephens R;Baseler MW;Lane HC;Lempicki RA
通讯作者：
Lempicki RA
RNA m6A 阅读器 YTHDF2 通过靶向 AXIN1/Wnt/β-catenin 信号传导促进肺腺癌细胞增殖和转移
影响因子：
9
作者：
Li Y;Sheng H;Ma F;Wu Q;Huang J;Chen Q;Sheng L;Zhu X;Zhu X;Xu M
通讯作者：
Xu M
m(6)A mRNA甲基化调控CTNNB1促进肝母细胞瘤增殖
影响因子：
37.3
作者：
Liu, Li;Wang, Jing;Pan, Qiuhui
通讯作者：
Pan, Qiuhui
影响因子：
6.4
作者：
Dolores Tabernero, Maria;Maillo, Angel;Orfao, Alberto
通讯作者：
Orfao, Alberto
影响因子：
4
作者：
Chen, Xiaodong;Tian, Fen;Feng, Yugong
通讯作者：
Feng, Yugong