Role of actin cytoskeleton in podocytes.
Role of actin cytoskeleton in podocytes.
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肌动蛋白细胞骨架在足细胞中的作用。
DOI：
10.1007/s00467-020-04812-z
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发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Sever S
中科院分区：
文献类型：
--
作者：
Sever S
肾小球滤过器的选择性是通过其三个核心成分（肾小球内皮细胞、肾小球基底膜和足细胞）之间的物理、化学和信号相互作用建立的。这三种成分中任何一种的功能障碍或损伤都可能导致蛋白尿。足细胞在许多人类和实验性肾小球疾病中受到损伤，包括微小病变病、局灶节段性肾小球硬化和糖尿病。足细胞损伤的最早迹象之一是其独特结构的丧失，这是由肌动蛋白细胞骨架的失调动力学驱动的。足细胞中肌动蛋白细胞骨架的状态取决于一组肌动蛋白结合蛋白、肌动蛋白聚合的成核剂和抑制剂以及调节性GTP酶。在人类和动物模型中，改变每类蛋白质功能的突变与肾小球疾病有关。此外，越来越多的研究表明，肌动蛋白细胞骨架的药理学修饰有可能成为足细胞依赖性慢性肾脏疾病的新疗法。本文综述了足细胞中形成肌动蛋白细胞骨架的重要蛋白质，以及在肾脏疾病中应用肌动蛋白细胞骨架药物的可行性研究。
The selectivity of the glomerular filter is established by physical, chemical, and signaling interplay among its three core constituents: glomerular endothelial cells, the glomerular basement membrane and podocytes. Functional impairment or injury of any of these three components can lead to proteinuria. Podocytes are injured in many forms of human and experimental glomerular disease, including minimal change disease, focal segmental glomerulosclerosis and diabetes mellitus. One of the earliest signs of podocyte injury is loss of their distinct structure, which is driven by dis-regulated dynamics of the actin cytoskeleton. Status of the actin cytoskeleton in podocytes depends on a set of actin binding proteins, nucleators and inhibitors of actin polymerization, and regulatory GTPases. Mutations that alter protein function in each category have been implicated in glomerular diseases in humans and animal models. In addition, a growing body of studies suggest that pharmacological modifications of the actin cytoskeleton have the potential to become novel therapeutics for podocyte-dependent chronic kidney diseases. This review presents an overview of the essential proteins that establish actin cytoskeleton in podocytes and studies demonstrating the feasibility of drugging actin cytoskeleton in kidney diseases.
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影响因子：
13.6
作者：
Lee, Ha Won;Khan, Samia Q.;Gupta, Vineet
通讯作者：
Gupta, Vineet
影响因子：
19.6
作者：
通讯作者：
--
DOI：
10.1038/nrm2867
发表时间：
2010-04
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
通讯作者：
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影响因子：
21.3
作者：
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通讯作者：
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影响因子：
13.6
作者：
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通讯作者：
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