Changes in immune responses to mite antigen sensitized through barrier-disrupted skin with CpG-oligodeoxynucleotide in mice
Changes in immune responses to mite antigen sensitized through barrier-disrupted skin with CpG-oligodeoxynucleotide in mice
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DOI：
10.1248/bpb.29.385
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发表时间：
2006-02-01
影响因子：
2
通讯作者：
Aramaki, Y
中科院分区：
文献类型：
--
作者：
Inoue, J;Yotsumoto, S;Aramaki, Y
CpG-ODN（CpG-oligodeoxynucleotide）通过增强Th 1和抑制Th 2应答在免疫中发挥重要作用。本研究观察CpG-ODN对螨抗原致敏的人特应性皮炎（AD）模型小鼠屏障破坏皮肤免疫应答的影响。虽然螨抗原致敏诱导的Th 2优势免疫应答，CpG-ODN的共同管理引起的Th 1优势免疫应答。在抗原特异性抗体产生方面，IgG 2a的水平被CpG-ODN增加，但不增加IgE。这些结果表明，CpG-ODN通过皮肤给药是一种简单的策略，用于患有AD等疾病的患者，其特征在于Th 2主导的炎症。
CpG-oligodeoxynucleotide (CpG-ODN) plays a critical role in immunity via the augmentation of Th1 and suppression of Th2 responses. We examined here the effect of CpG-ODN on the immune response to mite antigen sensitized through barrier-disrupted skin of human atopic dermatitis (AD) model mouse. Although sensitization with mite antigen induced Th2-dominant immune response, co-administration of CpG-ODN elicited Th1-predominant immune response. In terms of antigen-specific antibody production, the level of IgG2a was increased by CpG-ODN, but not in IgE. These results suggested that administration of CpG-ODN via skin is a simple strategy for patients with diseases like AD, which is characterized by Th2-dominated inflammation.