Comparison between 3 triclosan dentifrices on plaque, gingivitis and salivary microflora.
Comparison between 3 triclosan dentifrices on plaque, gingivitis and salivary microflora.
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3 种三氯生牙膏对牙菌斑、牙龈炎和唾液微生物菌群的影响比较。
DOI：
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发表时间：
2005
影响因子：
6.7
通讯作者：
D. Birkhed
中科院分区：
文献类型：
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作者：
S. Renvert;D. Birkhed
在一项为期 6 个月、无人监督的刷牙研究中对 3 种含三氯生的牙膏进行了比较。评估了对牙菌斑、牙龈出血和某些唾液微生物（变形链球菌、乳酸杆菌、链球菌总数和微生物总数）的影响。 123名受试者根据牙龈出血指数的严重程度分为4组。 112 名受试者完成了研究。经过 4 周的实验前阶段，使用单氟磷酸钠牙膏（安慰剂），受试者被分配使用瑞典市场上出售的 3 种含三氯生牙膏中的一种：高露洁 Paradent（三氯生/共聚物牙膏）（n = 26）； Pepsodent Gum Health（三氯生/柠檬酸锌牙膏）（n = 31）； Dentosal Friskt Tandkött（一种三氯生/焦磷酸盐洁齿剂）（n = 28）；或继续使用安慰剂 (n = 27)。结果显示，在 6 个月的实验期间，高露洁 Paradent 将基线菌斑值降低了 39%（Quigley 和 Hein）。其他方式的相应值是：Pepsodent Gum Health 减少 6%，Dentosal Friskt Tandkött 增加 5%，安慰剂增加 2%。高露洁 Paradent 和 Pepsodent Gum Health 之间以及高露洁 Paradent 和安慰剂之间的牙菌斑水平存在显着差异 (p < 0.05)。 4组的牙龈出血指数均有所改善。在 3 个月登记时，发现高露洁 Paradent 和安慰剂 (p < 0.05) 之间的出血情况存在显着差异 (p < 0.05)。随着时间的推移，Dentosal、Pepsodent 和安慰剂组的链球菌总数和菌落形成单位总数出现了统计上显着的增加，但高露洁则没有。（摘要截断为 250 字）
3 triclosan-containing dentifrices were compared in a 6-month, unsupervised tooth brushing study. The effects on plaque, gingival bleeding and certain salivary micro-organisms (mutans streptococci, lactobacilli, total counts of streptococci and total counts of micro-organisms) were evaluated. 123 subjects were divided into 4 groups according to severity of gingival bleeding index. 112 subjects completed the study. Following a 4-week pre-experimental period, using a sodium monofluorophosphate dentifrice (placebo), the subjects were assigned to use one of 3 triclosan-containing dentifrices, available on the Swedish market: Colgate Paradent (a triclosan/copolymer dentifrice) (n = 26); Pepsodent Gum Health (a triclosan/zinc citrate dentifrice) (n = 31); Dentosal Friskt Tandkött (a triclosan/pyrophosphate dentifrice) (n = 28); or to continue with the placebo (n = 27). The results revealed that Colgate Paradent reduced baseline plaque values by 39% (Quigley and Hein) over the 6-month experimental period. The corresponding values for the other modalities were: a reduction of 6% for Pepsodent Gum Health, an increase of 5% for Dentosal Friskt Tandkött, and an increase of 2% for placebo. A significant difference in the plaque levels (p < 0.05) was found between Colgate Paradent and Pepsodent Gum Health and between Colgate Paradent and placebo. The gingival bleeding index was improved in all 4 groups. A significant difference (p < 0.05) was found with respect to bleeding between Colgate Paradent and placebo (p < 0.05) at the 3-month registration. A statistically significant increase over time in total number of streptococci and total colony forming units were found for the Dentosal, Pepsodent and placebo groups, but not for Colgate.(ABSTRACT TRUNCATED AT 250 WORDS)