Studies of neoplastic development in respiratory tract epithelium.
Studies of neoplastic development in respiratory tract epithelium.
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呼吸道上皮肿瘤发展的研究。
DOI：
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发表时间：
1981
影响因子：
4.6
通讯作者：
D. C. Topping
中科院分区：
文献类型：
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作者：
P. Nettesheim;Andres J Klein;A. Marchok;V. Steele;Margaret Terzaghi;D. C. Topping
采用形态学和组织培养技术，在动物模型中研究了传导气道中肿瘤发展的动力学。提供了许多化生-异型增生病变（包括晚期“瘤前”病变）消退的证据。病变的消退并不等同于肿瘤过程的逆转。致癌物暴露后，“致癌物改变”的细胞数量和具有肿瘤潜能的细胞数量继续增加，作为时间的函数。利用为这些研究开发的细胞培养方法，可以定性和定量分析体内发生的肿瘤过程的进展，并检测和计数后期出现的癌症的祖细胞。研究还提供了强有力的证据，表明暴露于致癌物的器官含有更多具有肿瘤潜力的细胞。然而，当允许或促进条件占上风时，这种表达可能会急剧加强。这些研究开辟了新的途径，以开发用于检测癌前细胞群和在肿瘤疾病过程的早期阶段进行治疗干预的手段。
The dynamics of neoplastic development in conducting airways were studied in an animal model using morphologic and tissue culture techniques. Evidence for the regression of many metaplastic-dysplastic lesions, including advanced "preneoplastic" lesions, was provided. This regression of lesions is not synonymous with reversion of the neoplastic process. The number of "carcinogen-altered" cells and the number of cells with neoplastic potential continued to increase as a function of time after carcinogen exposure. With the cell culture methods developed for these studies, it is possible to analyze qualitatively and quantitatively the progression of the neoplastic process as it takes place in vivo and to detect and enumerate the progenitor cells of later-appearing cancers. The investigations also provide strong evidence suggesting that carcinogen-exposed organs contain many more cells with neoplastic potential. This expression may, however, be sharply enhanced when permissive or promoting conditions prevail. The investigations open up new avenues to develop means for detection of preneoplastic cell populations and for therapeutic intervention during early phases of the neoplastic disease process.