The role of myocardial innervation imaging in different clinical scenarios: an expert document of the European Association of Cardiovascular Imaging and Cardiovascular Committee of the European Association of Nuclear Medicine
The role of myocardial innervation imaging in different clinical scenarios: an expert document of the European Association of Cardiovascular Imaging and Cardiovascular Committee of the European Association of Nuclear Medicine
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DOI：
10.1093/ehjci/jeab007
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发表时间：
2021-02-01
影响因子：
6.2
通讯作者：
Slart, Riemer H. J. A.
中科院分区：
文献类型：
--
作者：
Gimelli, Alessia;Liga, Riccardo;Slart, Riemer H. J. A.
心脏交感神经活动在健康和疾病条件下支持心脏功能方面发挥着关键作用，核心脏成像一直是非侵入性评估心脏交感神经末梢功能完整性的唯一方法，主要通过使用去甲肾上腺素类似物的放射性药物，特别是使用 I-123-mIBG 成像。该技术证明了不同心脏病中存在心脏交感功能障碍，将交感神经系统损伤的严重程度与患者的不良预后联系起来。本文将概述心脏 I-123-mIBG 成像的最新技术，并定义其在心血管疾病不同领域的价值和临床应用。
Cardiac sympathetic activity plays a key role in supporting cardiac function in both health and disease conditions, and nuclear cardiac imaging has always represented the only way for the non-invasive evaluation of the functional integrity of cardiac sympathetic terminals, mainly through the use of radiopharmaceuticals that are analogues of norepinephrine and, in particular, with the use of I-123-mIBG imaging. This technique demonstrates the presence of cardiac sympathetic dysfunction in different cardiac pathologies, linking the severity of sympathetic nervous system impairment to adverse patient's prognosis. This article will outline the state-of-the-art of cardiac I-123-mIBG imaging and define the value and clinical applications in the different fields of cardiovascular diseases.