Neural correlates of the precedence effect in the inferior colliculus of behaving cats.
Neural correlates of the precedence effect in the inferior colliculus of behaving cats.
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DOI：
10.1152/jn.00606.2004
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发表时间：
2004-12
影响因子：
2.5
通讯作者：
D. Tollin;L. Populin;T. Yin
中科院分区：
文献类型：
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作者：
D. Tollin;L. Populin;T. Yin
几种听觉空间错觉，统称为优先效应（PE），发生在瞬态声音从两个不同的空间位置，但在时间上分开的刺激间延迟（ISD）。对于定位优势范围（<10 ms）内的ISD，单个融合声音通常仅位于领先声源位置附近，就好像滞后声源的位置被抑制一样。对于较长的ISD，可以听到和定位超前和滞后源，并且发生这种情况的最短ISD称为回声阈值。以前的生理学研究的单个神经元的细胞外反应在下丘（IC）的麻醉猫和未麻醉的兔子与已知的声音引起的PE显示这些现象的相关性，虽然有生理测量的回声阈值的差异。在这里，我们记录了清醒的IC，行为猫使用刺激，我们已经表明，唤起行为反应，是一致的优先效应。对于小ISDs，响应滞后减少或消除一致的心理物理数据表明，声音定位是基于领先的来源。在较长的ISD，滞后源的反应恢复在ISD可比的精神病测量的回声阈值。因此，似乎麻醉，而不是物种差异，解释了早期研究中的差异。
Several auditory spatial illusions, collectively called the precedence effect (PE), occur when transient sounds are presented from two different spatial locations but separated in time by an interstimulus delay (ISD). For ISDs in the range of localization dominance (<10 ms), a single fused sound is typically located near the leading source location only, as if the location of the lagging source were suppressed. For longer ISDs, both the leading and lagging sources can be heard and localized, and the shortest ISD where this occurs is called the echo threshold. Previous physiological studies of the extracellular responses of single neurons in the inferior colliculus (IC) of anesthetized cats and unanesthetized rabbits with sounds known to elicit the PE have shown correlates of these phenomena though there were differences in the physiologically measured echo thresholds. Here we recorded in the IC of awake, behaving cats using stimuli that we have shown to evoke behavioral responses that are consistent with the precedence effect. For small ISDs, responses to the lag were reduced or eliminated consistent with psychophysical data showing that sound localization is based on the leading source. At longer ISDs, the responses to the lagging source recovered at ISDs comparable to psychophysically measured echo thresholds. Thus it appears that anesthesia, and not species differences, accounts for the discrepancies in the earlier studies.