Cyclin D1 and Ewing's sarcoma/PNET: A microarray analysis
Cyclin D1 and Ewing's sarcoma/PNET: A microarray analysis
复制标题
DOI：
10.1016/j.acthis.2015.08.006
复制
发表时间：
2015-01-01
影响因子：
2.5
通讯作者：
Magro, Gaetano
中科院分区：
文献类型：
--
作者：
Fagone, Paolo;Nicoletti, Ferdinando;Magro, Gaetano
最近的免疫组化分析表明，细胞周期蛋白D1表达在软组织尤文氏肉瘤/外周神经外胚层肿瘤（PNET）的儿童和青少年，而它是检测不到的胚胎和腺泡状横纹肌肉瘤。在本文中，微阵列分析提供了证据表明，一个显着上调细胞周期蛋白D1在尤文氏肉瘤相比，正常组织。此外，我们证实了我们以前的研究结果，一个显着的过度表达细胞周期蛋白D1尤文肉瘤相比，横纹肌肉瘤。生物信息学分析还允许识别一些与细胞周期蛋白D1密切相关的其他基因，尽管以前没有在儿科肿瘤中研究过，但这些基因可能代表尤文肉瘤/PNET诊断和预后的新标志物。本文提供的数据不仅支持使用细胞周期蛋白D1作为尤文肉瘤/PNET的诊断标志物，而且支持使用靶向细胞周期蛋白D1的药物作为潜在治疗策略的可能性。(C)2015 Elsevier GmbH. All rights reserved.
Recent immunohistochemical analyses have showed that cyclin D1 is expressed in soft tissue Ewing's sarcoma/peripheral neuroectodermal tumor (PNET) of childhood and adolescents, while it is undetectable in both embryonal and alveolar rhabdomyosarcoma. In the present paper, microarray analysis provided evidence of a significant upregulation of cyclin D1 in Ewing's sarcoma as compared to normal tissues. In addition, we confirmed our previous findings of a significant over-expression of cyclin D1 in Ewing sarcoma as compared to rhabdomyosarcoma. Bioinformatic analysis also allowed to identify some other genes, strongly correlated to cyclin D1, which, although not previously studied in pediatric tumors, could represent novel markers for the diagnosis and prognosis of Ewing's sarcoma/PNET. The data herein provided support not only the use of cyclin D1 as a diagnostic marker of Ewing sarcoma/PNET but also the possibility of using drugs targeting cyclin D1 as potential therapeutic strategies. (C) 2015 Elsevier GmbH. All rights reserved.