COMPARATIVE PHARMACOKINETICS OF FENTANYL AND ALFENTANIL
COMPARATIVE PHARMACOKINETICS OF FENTANYL AND ALFENTANIL
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DOI：
10.1093/bja/54.8.871
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发表时间：
1982-01-01
影响因子：
9.8
通讯作者：
HULL, CJ
中科院分区：
文献类型：
--
作者：
BOWER, S;HULL, CJ
通过同时静脉注射芬太尼和阿芬太尼（阿片类药物）、测定血浆浓度和室室分析，比较两种药物的药代动力学。比较血浆蛋白结合、红细胞：血浆分割、庚烷：水分割。阿芬太尼在血浆中的表观分布体积小，总清除率小，终末半衰期短。与芬太尼相比，阿芬太尼有更强的血浆蛋白结合，但不与红细胞结合。显然，阿芬太尼的累积性比芬太尼小，肝脏清除率有限，并且在非常高剂量时表现出非线性动力学。
The pharmacokinetics of fentanyl and alfentanil [opioids] were compared by the simultaneous i.v. administration of both drugs [to humans], measurement of plasma concentrations and compartmental analysis. Plasma protein binding, erythrocyte:plasma partition, and heptane:H2O partition were compared. Alfentanil had a much smaller apparent volume of distribution, smaller total clearance and shorter terminal half-time in plasma. Alfentanil had a greater plasma protein binding but, in contrast to fentanyl, no binding to erythrocytes. Evidently, alfentanil is less cumulative than fentanyl, has restricted hepatic clearance, and exhibits nonlinear kinetics at very high doses.