The rat suprachiasmatic nucleus is a clock for all seasons.
The rat suprachiasmatic nucleus is a clock for all seasons.
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大鼠视交叉上核是四季的时钟。
DOI：
10.1073/pnas.92.17.7754
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发表时间：
1995
影响因子：
11.1
通讯作者：
Illnerová,H
中科院分区：
文献类型：
--
作者：
Sumová,A;Trávnícková,Z;Peters,R;Schwartz,WJ;Illnerová,H
日长（光周期）的季节性变化影响各种生物体内激素和行为昼夜节律的表达。在哺乳动物中，这种效应可能反映了昼夜节律起搏系统（位于下丘脑的视交叉上核（SCN））中的光周期变化，该系统控制这些节律，但迄今为止，尚未发现SCN的功能相关内在特性具有光周期依赖性。我们分析了光诱导的c-fos基因表达的时间调节大鼠SCN维持在长或短的光周期。原位杂交和免疫组织化学分析均表明，SCN光反应的内源性昼夜节律受光周期的影响，短光周期下的光敏主观夜持续时间比长光周期下长5-6 h。我们的研究结果提供的证据表明，SCN的功能特性被改变的光周期，并建议参与光周期时间测量的核。
Seasonal changes of daylength (photoperiod) affect the expression of hormonal and behavioral circadian rhythms in a variety of organisms. In mammals, such effects might reflect photoperiodic changes in the circadian pace-making system [located in the suprachiasmatic nucleus (SCN) of the hypothalamus] that governs these rhythms, but to date no functionally relevant, intrinsic property of the SCN has been shown to be photoperiod dependent. We have analyzed the temporal regulation of light-induced c-fos gene expression in the SCN of rats maintained in long or short photoperiods. Both in situ hybridization and immunohistochemical assays show that the endogenous circadian rhythm of light responsiveness in the SCN is altered by photoperiod, with the duration of the photosensitive subjective night under the short photoperiod 5-6 h longer than under the long photoperiod. Our results provide evidence that a functional property of the SCN is altered by photoperiod and suggest that the nucleus is involved in photoperiodic time measurement.