MUSCLE-FIBER DEGENERATION AND NECROSIS IN MUSCULAR-DYSTROPHY AND OTHER MUSCLE DISEASES - CYTOCHEMICAL AND IMMUNOCYTOCHEMICAL DATA
MUSCLE-FIBER DEGENERATION AND NECROSIS IN MUSCULAR-DYSTROPHY AND OTHER MUSCLE DISEASES - CYTOCHEMICAL AND IMMUNOCYTOCHEMICAL DATA
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DOI：
10.1002/ana.410160612
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发表时间：
1984-01-01
影响因子：
11.2
通讯作者：
DONES, I
中科院分区：
文献类型：
--
作者：
CORNELIO, F;DONES, I
Serial consecutive frozen sections from 164 muscle biopsy specimens were studied cytochemically. Ca and albumin were localized as endogenous markers of extracellular fluid penetration and C3 and C9 complement components as markers of muscles fiber necrosis. In both Duchenne dystrophy and congenital muscular dystrophy, a significant percentage of fibers were overloaded with Ca and penetrated by albumin. Most of these fibers appeared opaque with trichrome stain. C3 and C9 complement components appeared only in necrotic fibers, which invariably were also penetrated by albumin. Muscle fiber necrosis is linked to massive inflow of extracellular fluid and complement activation. In both Duchenne and congenital dystrophies, numerous nonnecrotic fibers are penetrated by Ca-rich extracellular fluid.
