Immunohistochemistry in the diagnosis and classification of neuroendocrine neoplasms: what can brown do for you?
Immunohistochemistry in the diagnosis and classification of neuroendocrine neoplasms: what can brown do for you?
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DOI：
10.1016/j.humpath.2019.12.002
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发表时间：
2020-02-01
期刊：
影响因子：
3.3
通讯作者：
Bellizzi, Andrew M.
中科院分区：
文献类型：
--
作者：
Bellizzi, Andrew M.
本综述基于2019年美国和加拿大病理学学会年会上Hans Popper肝脏病理学学会同伴会议上的演讲。它介绍了神经内分泌肿瘤的诊断和分类的最新情况，重点是免疫组织化学的作用。神经内分泌肿瘤通常在肝活检中表现为隐匿性来源的转移瘤。所涉及的具体问题包括1。神经内分泌肿瘤的一般特征，2.一般神经内分泌标志物免疫组化，与新兴的标志物INSM 1，3的讨论。非小细胞癌伴（隐匿性）神经内分泌分化，4. WHO神经内分泌肿瘤分类，讨论2019年胃肠胰腺肿瘤分类，5。Ki-67免疫组化的应用，6.免疫组化对隐匿性神经内分泌转移灶定位，7.免疫组化区分高分化神经内分泌肿瘤G3和低分化神经内分泌癌，8.常误诊为高分化神经内分泌肿瘤;使用相关免疫组织化学染色进行活检和切除所需和推荐的数据元素。下一代免疫组织化学，包括谱系限制性转录因子（例如，CDX 2、胰岛1、OTP、SATB 2）和分子遗传事件的蛋白质相关物（例如，p53，Rb），是必不可少的准确诊断和分类这些肿瘤。(C)2019爱思唯尔公司All rights reserved.
This review is based on a presentation given at the Hans Popper Hepatopathology Society companion meeting at the 2019 United States and Canadian Academy of Pathology Annual Meeting. It presents updates on the diagnosis and classification of neuroendocrine neoplasms, with an emphasis on the role of immunohistochemistry. Neuroendocrine neoplasms often present in liver biopsies as metastases of occult origin. Specific topics covered include 1. general features of neuroendocrine neoplasms, 2. general neuroendocrine marker immunohistochemistry, with discussion of the emerging marker INSM1, 3. nonsmall cell carcinoma with (occult) neuroendocrine differentiation, 4. the WHO Classification of neuroendocrine neoplasms, with discussion of the 2019 classification of gastroenteropancreatic neoplasms, 5. use of Ki-67 immunohistochemistry, 6. immunohistochemistry to assign site of origin in neuroendocrine metastasis of occult origin, 7. immunohistochemistry to distinguish well-differentiated neuroendocrine tumor G3 from poorly differentiated neuroendocrine carcinoma, 8. lesions frequently misdiagnosed as well-differentiated neuroendocrine tumor, and 9. required and recommended data elements for biopsies and resections with associated immunohistochemical stains. Next-generation immunohistochemistry, including lineage-restricted transcription factors (e.g., CDX2, islet 1, OTP, SATB2) and protein correlates of molecular genetic events (e.g., p53, Rb), is indispensable for the accurate diagnosis and classification of these neoplasms. (C) 2019 Elsevier Inc. All rights reserved.