The importance of a satisfactory biopsy for the diagnosis of lung cancer in the era of personalized treatment
The importance of a satisfactory biopsy for the diagnosis of lung cancer in the era of personalized treatment
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DOI：
10.3747/co.19.1062
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发表时间：
2012-06-01
期刊：
影响因子：
2.6
通讯作者：
Gonzalez, A. V.
中科院分区：
文献类型：
--
作者：
Ofiara, L. M.;Navasakulpong, A.;Gonzalez, A. V.
分子生物学的进展正在提高人们对肺癌的认识，并改变治疗方法。一个令人满意的活检，允许组织学特征和突变分析正变得越来越重要。大多数肺癌患者是在晚期被诊断出来的，诊断通常是基于小的活检或细胞学标本。在这里，我们回顾了可用于肺癌诊断的技术，包括支气管镜检查、超声引导下的支气管镜检查、纵隔镜检查、经胸针吸、胸腔穿刺术和内科胸腔镜检查。我们还讨论了这些技术的适应症、并发症和组织产量，特别是当它们与分子标记检测有关时。
Advances in molecular biology are improving the understanding of lung cancer and changing the approach to treatment. A satisfactory biopsy that allows for histologic characterization and mutation analysis is becoming increasingly important. Most patients with lung cancer are diagnosed at an advanced stage, and diagnosis is often based on a small biopsy or cytology specimen. Here, we review the techniques available for making a diagnosis of lung cancer, including bronchoscopy, ultrasound-guided bronchoscopy, mediastinoscopy, transthoracic needle aspiration, thoracentesis, and medical thoracoscopy. We also discuss the indications, complications, and tissue yields of those techniques, especially as they pertain to testing for molecular markers.