Polarity of long-term synaptic gain change is related to postsynaptic spike firing at a cerebellar inhibitory synapse
Polarity of long-term synaptic gain change is related to postsynaptic spike firing at a cerebellar inhibitory synapse
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DOI：
10.1016/s0896-6273(00)80598-x
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发表时间：
1998-10-01
期刊：
影响因子：
16.2
通讯作者：
Linden, DJ
中科院分区：
文献类型：
--
作者：
Aizenman, CD;Manis, PB;Linden, DJ
兴奋性突触中的长时程增强和抑制（LTP和LTD）可以共存，前者由产生强突触后兴奋的刺激触发，后者由产生弱突触后兴奋的刺激触发。尚未确定这些特性是否也适用于浦肯野神经元和小脑深核（DCN）神经元之间的抑制性突触中的LTP和LTD，该部位与某些类型的运动学习有关。DCN细胞表现出显著的反弹去极化（RD）和相关的尖峰爆发后释放超极化。在这些细胞中，LTP可以由短的、高频率的抑制性突触后电位（IPSP）引起，这可靠地引起RD。如果在突触后兴奋量减少的条件下应用相同的方案，则诱导LTD。突触强度变化的极性与诱导过程中RD诱发的尖峰放电量相关。因此，一些重要的计算原则，支配兴奋性突触功效的使用依赖性变化的诱导也适用于抑制性突触。
Long-term potentiation and depression (LTP and LTD) in excitatory synapses can coexist, the former being triggered by stimuli that produce strong postsynaptic excitation and the latter by stimuli that produce weaker postsynaptic excitation. It has not been determined whether these properties also apply to LTP and LTD in the inhibitory synapses between Purkinje neurons and the neurons of the deep cerebellar nuclei (DCN), a site that has been implicated in certain types of motor learning. DCN cells exhibit a prominent rebound depolarization (RD) and associated spike burst upon release from hyperpolarization. In these cells, LTP can be elicited by short, high-frequency trains of inhibitory postsynaptic potentials (IPSPs), which reliably evoke an RD. LTD is induced if the same protocol is applied with conditions where the amount of postsynaptic excitation is reduced. The polarity of the change in synaptic strength is correlated with the amount of RD-evoked spike firing during the induction protocol. Thus, some important computational principles that govern the induction of use-dependent change in excitatory synaptic efficacy also apply to inhibitory synapses.