Pain aversion and anxiety-like behavior occur at different times during the course of chronic inflammatory pain in rats.
Pain aversion and anxiety-like behavior occur at different times during the course of chronic inflammatory pain in rats.
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DOI：
10.2147/jpr.s139679
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发表时间：
2017
影响因子：
2.7
通讯作者：
Fang J
中科院分区：
文献类型：
--
作者：
Wu Y;Yao X;Jiang Y;He X;Shao X;Du J;Shen Z;He Q;Fang J
疼痛被认为是一种多维的意识体验，包括感觉成分和消极的情感动机成分。疼痛的消极情感动机成分与感觉成分不同，它放大了疼痛体验。如今，相当数量的临床前研究小组已经将注意力集中在疼痛的情感症状上。在本研究中，我们研究了完全弗氏佐剂（CFA）诱导的慢性疼痛模型的疼痛厌恶和焦虑样行为。CFA大鼠在疼痛配对条件反射（疼痛厌恶）期间经历自发性疼痛，并且自发性疼痛产生情感反应（焦虑样行为）。此外，疼痛厌恶逐渐减弱，而焦虑样行为在4周内增加。因此，尽管疼痛的负性效应（包括疼痛厌恶和焦虑）总是伴随着痛觉过敏，但这些负性效应的表现可能遵循不同的时间进程，从而影响原发病的进展。研究结果表明，靶向治疗应侧重于疼痛不同阶段的特定方面。我们的研究强调了使用多种测试来研究疼痛合并症的必要性。
Pain is considered a multidimensional conscious experience that includes a sensory component and a negative affective-motivational component. The negative affective-motivational component of pain is different from the sensory component and amplifies the pain experience. Nowadays, a significant number of preclinical research groups have focused their attention on the affective symptoms of pain. In the present study, we investigated the pain aversion and anxiety-like behavior of the complete Freund’s adjuvant (CFA)-induced chronic pain model. CFA rats experienced spontaneous pain during pain-paired conditioning (pain aversion) and spontaneous pain produces an affective response (anxiety-like behavior). Moreover, pain aversion was gradually attenuated, while the anxiety-like behavior increased in 4 weeks. Therefore, although the negative effect (including pain aversion and anxiety) is always associated with hyperalgesia, the manifestations of negative effect may follow different time courses, which may influence the progress of primary disease. The findings illustrate that targeted therapy should focus on a specific aspect in different stages of pain. Our study emphasizes the necessity of using multiple tests to study pain comorbidities.