SUBSTANTIA NIGRA AS A STATION THAT NOT ONLY TRANSMITS, BUT ALSO TRANSFORMS, INCOMING SIGNALS FOR ITS BEHAVIORAL EXPRESSION - STRIATAL DOPAMINE AND GABA-MEDIATED RESPONSES OF PARS RETICULATA NEURONS
SUBSTANTIA NIGRA AS A STATION THAT NOT ONLY TRANSMITS, BUT ALSO TRANSFORMS, INCOMING SIGNALS FOR ITS BEHAVIORAL EXPRESSION - STRIATAL DOPAMINE AND GABA-MEDIATED RESPONSES OF PARS RETICULATA NEURONS
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DOI：
10.1016/0166-4328(83)90003-7
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发表时间：
1983-01-01
影响因子：
2.7
通讯作者：
WOLFARTH, S
中科院分区：
文献类型：
--
作者：
COOLS, AR;JASPERS, R;WOLFARTH, S
为了研究纹状体多巴胺能机制是否参与黑质网状部 GABA 能机制的行为表达，将阿扑吗啡或氟哌啶醇双侧注射到猫的尾状核中，并用单侧印防己毒素或蝇蕈醇注射到黑质网状部进行预处理。尽管为尾状核注射选择的剂量对于影响尾状核功能的行为表达是最有效的，但尾状核的药物治疗并没有对黑质引起的行为产生任何显着的变化；印防己毒素引起的不对称姿势、不对称转圈、冻结和后腿障碍以及蝇蕈醇引起的不对称姿势、不对称旋转和定型舔舐均未受到显着影响。黑质网状部部分或全部破坏的动物不存在后一种行为。由于黑质网状部的行为表达与尾状核的不对称头部扭转特征完全不同，尾状核的行为表达需要大脑其他地方的主要输出站。黑质网状部并不构成反馈系统的重要组成部分，该反馈系统只是将来自尾状核的输入信号传输到致密部，即多巴胺能黑质纹状体系统的起源。尾状核内的多巴胺能活性可能仅改变但肯定不能决定黑质网状部的行为表达。因此，黑质网状部不仅传输，而且还转换其输入信号。
In order to investigate whether striatal dopaminergic mechanisms are involved in the behavioral expression of the GABAergic mechanisms within the pars reticulata of the substantia nigra, apomorphine or haloperidol were bilaterally administered into the caudate nucleus of cats pretreated with a unilateral injection of picrotoxin or muscimol into the nigral pars reticulata. Although the doses selected for the intracaudate injections are maximally effective in affecting the behavioral expression of the caudate function, the pharmacological treatment of the caudate nucleus did not produce any significant change in the behavior elicited from the nigra; neither the picrotoxin-induced asymmetric posturing, asymmetric circling, freezing and hind leg disorders nor the muscimol-induced asymmetric posturing, asymmetric spinning and stereotyped licking were significantly affected. The latter behavior was absent in animals with a partial or total destruction of the nigral pars reticulata. As the behavioral expression of the nigral pars reticulata differed completely from the asymmetric head twisting characteristic for the caudate nucleus, the behavioral expression of the caudate nucleus requires a main output station elsewhere in the brain. The nigral pars reticulata does not form part and parcel of a feedback system that simply transmits incoming signals from the caudate nucleus towards the pars compacta, i.e. the origin of the dopaminergic, nigrostriatal system. The dopaminergic activity within the caudate nucleus may only modify, but certainly not determine, the behavioral expression of the nigral pars reticulata. Thus, the nigral pars reticulata not only transmits, but also transforms its incoming signals.