Membrane trafficking in podocyte health and disease.
Membrane trafficking in podocyte health and disease.
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DOI：
10.1007/s00467-012-2281-y
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发表时间：
2013-09
影响因子：
3
通讯作者：
Swiatecka-Urban, Agnieszka
中科院分区：
文献类型：
--
作者：
Swiatecka-Urban, Agnieszka
关键词：
足细胞是位于肾小球的高度特化的上皮细胞。不同的细胞信号事件和独特的细胞骨架结构使足细胞能够承受肾小球滤过过程中静水压的变化。肾小球滤过改变导致肾脏疾病，常表现为蛋白尿。人们越来越认识到，细胞信号传导和细胞骨架动力学与膜运输的耦合比以前认为的更紧密。膜运输协调蛋白质网络和信号级联之间的串扰，以空间和时间组织的方式，可以被视为细胞外部和内部之间的通信高速公路。膜运输包括将货物从质膜运输到细胞内部（即内吞作用），然后将货物运输到溶酶体进行降解或到质膜进行再循环。然而，最近的研究表明，传统的分类并不能完全反映膜运输的复杂性和多变性。虽然人们已经认识到足细胞中复杂的蛋白质支架和信号级联越来越复杂，但对膜运输的作用却知之甚少。本文就膜转运在足细胞健康和疾病中的作用作一综述。
Podocytes are highly specialized epithelial cells localized in the kidney glomerulus. The distinct cell signaling events and unique cytoskeletal architecture tailor podocytes to withstand changes in hydrostatic pressure during glomerular filtration. Alteration of glomerular filtration leads to kidney disease and frequently manifests with proteinuria. It has been increasingly recognized that cell signaling and cytoskeletal dynamics are coupled more tightly to membrane trafficking than previously thought. Membrane trafficking coordinates the cross-talk between protein networks and signaling cascades in a spatially and temporally organized fashion and may be viewed as a communication highway between the cell exterior and interior. Membrane trafficking involves transport of cargo from the plasma membrane to the cell interior (i.e., endocytosis) followed by cargo trafficking to lysosomes for degradation or to the plasma membrane for recycling. Yet, recent studies indicate that the conventional classification does not fully reflect the complex and versatile nature of membrane trafficking. While the increasing complexity of elaborate protein scaffolds and signaling cascades is being recognized in podocytes, the role of membrane trafficking is less well understood. This review will focus on the role of membrane trafficking in podocyte health and disease.
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