Diagnostic value of ascitic fluid cholesterol levels in the prediction of malignancy.
Diagnostic value of ascitic fluid cholesterol levels in the prediction of malignancy.
复制标题
DOI：
10.3109/00365528809090173
复制
发表时间：
1988-11
影响因子：
1.9
通讯作者：
P. Brøndum Mortensen;S. Dalby Kristensen;A. Bloch;B. Ascanius Jacobsen;S. Nørby Rasmussen
中科院分区：
文献类型：
--
作者：
P. Brøndum Mortensen;S. Dalby Kristensen;A. Bloch;B. Ascanius Jacobsen;S. Nørby Rasmussen
在一项前瞻性研究中，对54例原因不明的腹水患者进行了腹水穿刺。对腹水进行细胞学和细菌学检查。用酶比色法测定总胆固醇浓度。34例诊断为恶性疾病。其中2例同时患有恶性疾病和肝硬化，排除在外。17名患者患有肝硬化，1名患有急性胰腺炎，2名患有代偿性心脏病。腹水胆固醇浓度大于1.2 mmol/l预测恶性疾病的诊断价值为87.5%（95%置信限为71.0 ~ 96.5）。腹水胆固醇浓度小于或等于1.2 mmol/l对良性疾病的预测价值为80.0%（95%置信限，56.3-94.3）。结论：腹水胆固醇测定是细胞学检查鉴别恶性和良性腹水的有价值的补充。
In a prospective study abdominal paracentesis with ascitic fluid aspiration was performed in 54 consecutive patients with ascites of unknown cause. The ascitic fluid was examined cytologically and bacteriologically. The total cholesterol concentration was measured with an enzymatic colorimetric method. Malignant disease was diagnosed in 34 patients. Two of them had both malignant disease and liver cirrhosis and were excluded. Seventeen patients had liver cirrhosis, one had acute pancreatitis, and two had decompensated heart disease. The diagnostic value of an ascitic cholesterol concentration greater than 1.2 mmol/l in terms of predicting malignant disease was 87.5% (95% confidence limits, 71.0-96.5). The predictive value of an ascitic cholesterol concentration less than or equal to 1.2 mmol/l in terms of benign disease was 80.0% (95% confidence limits, 56.3-94.3). It is concluded that ascitic cholesterol measurement is a valuable supplement to cytologic examination in distinguishing between ascites of malignant and benign origin.