Beclin-1: Autophagic regulator and therapeutic target in cancer
Beclin-1: Autophagic regulator and therapeutic target in cancer
复制标题
DOI：
10.1016/j.biocel.2013.02.007
复制
发表时间：
2013-05-01
影响因子：
4
通讯作者：
Liu, Bo
中科院分区：
文献类型：
--
作者：
Fu, Lei-lei;Cheng, Yan;Liu, Bo
Beclin-1（酵母ATG 6的哺乳动物直系同源物）已被充分表征为在自噬中发挥关键作用，自噬是细胞降解大分子和受损细胞器的主要分解代谢途径。Beclin-1结构已被鉴定为包含三个可识别的结构域，包括短的Bcl-2-同源性-3（BH 3）基序、中央卷曲螺旋结构域（CCD）和C-末端半包围进化保守结构域（ECD）。最近的数据表明，Beclin-1可能与一些辅助因子如III类磷脂酰肌醇3-激酶（PI 3 KCIII）/Vps 34、Vps 15、ATG 14 L/Barkor、UVRAG、Bif-1、Rubicon、Ambra 1、HMGB 1、Survivin、Akt和Bcl-2/Bcl-X-L相互作用，以正向或负向协调Beclin-1相互作用组，从而共调节自噬过程。在这里，我们总结了Beclin-1不仅作为一个关键的自噬调节因子与其特定的相互作用，但作为一个潜在的治疗目标，在癌症。(C)2013爱思唯尔有限公司保留所有权利。
Beclin-1 (the mammalian ortholog of yeast ATG6) has been well-characterized to play a pivotal role in autophagy that is a major catabolic pathway in which the cell degrades macromolecules and damaged organelles. Beclin-1 structure has been identified to contain three identifiable domains, including a short Bcl-2-homology-3 (BH3) motif, a central coiled-coil domain (CCD) and a C-terminal half encompassing the evolutionarily conserved domain (ECD). Recent data indicate that Beclin-1 may interact with some co-factors such as Class III phosphatidylinositol 3-kinase (PI3KCIII)/Vps34, Vps15, ATG14L/Barkor, UVRAG, Bif-1, Rubicon, Ambra1, HMGB1, Survivin, Akt and Bcl-2/Bcl-X-L to positively or negatively orchestrate the Beclin-1 interactome, thereby co-regulating the autophagy process. Here, we summarize that Beclin-1 serves not only as a key autophagic regulator with its specific interactors, but as a potential therapeutic target in cancer. (C) 2013 Elsevier Ltd. All rights reserved.