Monosodium glutamate increases NGF and NPY concentrations in rat hypothalamus and pituitary
Monosodium glutamate increases NGF and NPY concentrations in rat hypothalamus and pituitary
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谷氨酸钠增加大鼠下丘脑和垂体中 NGF 和 NPY 的浓度
DOI：
10.1097/00001756-199512150-00003
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发表时间：
1995
期刊：
影响因子：
1.7
通讯作者：
L. Aloe
中科院分区：
文献类型：
--
作者：
P. Tirassa;T. Lundeberg;C. Stenfors;L. Bracci;E. Theodorsson;L. Aloe
分析了MSG对成年大鼠下丘脑、垂体、肾上腺、甲状腺和睾丸中NGF和NPY水平的影响。每天静脉注射味精（1 g kg-1，1周）诱导下丘脑中NGF的增加（对照组（C）= 378 ± 54;生理盐水（S）= 369 ± 36; MSG = 479 ± 35 pgg-1组织; p < 0.001）和垂体（C = 310 ± 34; S = 376 ± 114; MSG = 576 ± 98 pgg-1组织; p < 0.01）。下丘脑和垂体NPY浓度也在MSG处理的大鼠中改变。与生理盐水处理的大鼠相比，味精处理的大鼠下丘脑和垂体中的神经肽Y浓度分别增加了43%和37.5%。在治疗动物的肾上腺或甲状腺中未发现NGF和NPY含量的显著变化。这些结果表明，下丘脑和垂体的NGF和NPY水平可能参与控制的神经内分泌功能，受到味精治疗。
THE effects of MSG treatment on NGF and NPY levels were analysed in the hypothalamus, pituitary, adrenal, thyroid and testis of adult rats. Daily i.v. injections of MSG (1 gkg-1 for 1 week) induced an increase of NGF in the hypothalamus (control (C) = 378 ± 54; saline (S) = 369 ± 36; MSG = 479 ± 35pgg-1 tissue; p < 0.001) and pituitary (C = 310 ± 34; S = 376 ± 114; MSG = 576 ± 98pgg-1 tissue; p < 0.01). Hypothalamic and pituitary NPY concentrations were also altered in the MSG- treated rats. Compared with saline-treated rats, the NPY concentration increased by 43% in the hypothalamus and 37.5% in the pituitary of MSG-treated rats. No significant changes in NGF and NPY content were found in the adrenal or thyroid of treated animals. These results suggest that hypothalamic and pituitary NGF and NPY levels may be involved in the control of neuroendocrine functions that are affected by MSG treatment.