The Residual Medium and Long-term Cognitive Effects of Benzodiazepine Use: An Updated Meta-analysis
The Residual Medium and Long-term Cognitive Effects of Benzodiazepine Use: An Updated Meta-analysis
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DOI：
10.1093/arclin/acx120
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发表时间：
2018-11-01
影响因子：
2.6
通讯作者：
Stranks, Elizabeth K.
中科院分区：
文献类型：
--
作者：
Crowe, Simon F.;Stranks, Elizabeth K.
目的：本研究对苯二氮卓类药物对长期、当前使用这些药物的患者、最近戒断的患者和在戒断后成功戒烟的患者的认知功能的影响进行了最新荟萃分析。该研究是对我们小组先前发表的荟萃分析的更新。方法：对计算机数据库Medline和PsycINFO进行全面检索，以确定截至2016年11月28日（最后更新日期）发表的评估苯二氮卓类药物认知影响的研究。19项研究（8项研究发表以来，以前的荟萃分析和11项研究，包括在以前的studies）encountered.Results：当前用户的分析结果显示，统计学显着的，负面影响的认知领域的工作记忆，处理速度，分散注意力，visuoconstruction，最近的记忆，和表达语言。对于那些已经戒断并在戒断后成功戒断的人，观察到近期记忆、处理速度、视觉构建、分散注意力、工作记忆和持续注意力等领域的缺陷。这项研究的结果很重要，因为它们证实了越来越多的证据，即长期使用苯二氮卓类药物会损害一系列神经心理功能，而且即使在退出后，这些问题也可能持续存在。研究结果强调了与长期苯二氮卓类药物治疗相关的残余神经认知损害以及这些结果的重要临床意义。
Objective: This study presents an updated meta-analysis of the effects of benzodiazepines on cognitive functioning in long-term, current users of these agents, those who have recently withdrawn and on those who have successfully abstained following withdrawal. The study represents an update of the previous meta-analyses published by our group.Method: A comprehensive search of the computerized databases Medline and PsycINFO was undertaken to identify studies that assessed the cognitive effects of benzodiazepines published up to 28 November 2016 (the date of the last update). Nineteen studies (eight studies published since the previous meta-analyses and 11 studies included in the previous studies) were included.Results: The results of the analysis for current users revealed statistically significant, negative effects for the cognitive domains of working memory, processing speed, divided attention, visuoconstruction, recent memory, and expressive language. For those who had withdrawn and successfully abstained following withdrawal, deficits were observed for the domains of recent memory, processing speed, visuoconstruction, divided attention, working memory, and sustained attention.Conclusions: The results of the study are important in that they corroborate the mounting evidence that a range of neuropsychological functions are impaired as a result of long-term benzodiazepine use, and that these are likely to persist even following withdrawal. The findings highlight the residual neurocognitive compromise associated with long-term benzodiazepine therapy as well as the important clinical implications of these results.