Impact of angiotensin-converting enzyme inhibitors and statins on viral pneumonia.
Impact of angiotensin-converting enzyme inhibitors and statins on viral pneumonia.
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DOI：
10.1080/08998280.2018.1499293
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发表时间：
2018-10-01
期刊：
影响因子：
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通讯作者：
White, Heath D
中科院分区：
文献类型：
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作者：
Henry, Christopher;Zaizafoun, Manaf;White, Heath D
血管紧张素转换酶（ACE）抑制剂和他汀类药物可能对病毒感染和肺炎患者有益。我们的研究旨在评价ACE抑制剂和他汀类药物对病毒性肺炎患者插管率和死亡率的影响。我们回顾性研究了1055例在德克萨斯州中部三级护理中心住院的呼吸道病毒聚合酶链反应检测阳性的成人患者。其中，539例患者的临床表现和影像学表现与肺炎一致。我们收集了有关人口统计学特征、微生物学、共病、药物使用和结局的信息。入院前给予ACE抑制剂与死亡或插管风险增加相关（比值比[OR]=3.02; 95%置信区间[CI]，1.30-7.01），而入院前使用他汀类药物并没有改变死亡或插管率。住院期间继续使用ACE抑制剂（OR =0.25; 95% CI，0.09-0.64）和他汀类药物（OR =0.26; 95% CI，0.08-0.81）的死亡率和插管率较低。我们增加了进一步的证据，证明继续使用ACE抑制剂和他汀类药物对病毒性肺炎的有益作用。
Angiotensin-converting enzyme (ACE) inhibitors and statins may potentially benefit patients with viral infections and pneumonia. Our study aimed to evaluate the impact of ACE inhibitors and statins on the rates of intubation and death in viral pneumonia. We retrospectively studied 1055 adult patients admitted to a tertiary care center in central Texas with a positive respiratory viral polymerase chain reaction test. Of these, 539 had clinical presentation and imaging consistent with pneumonia. We collected information on demographic characteristics, microbiology, comorbid conditions, medication use, and outcomes. ACE inhibitors given prior to admission were associated with an increased risk of death or intubation (odds ratio [OR]=3.02; 95% confidence interval [CI], 1.30-7.01), whereas statin use prior to admission did not change rates of death or intubation. Lower rates of death and intubation were noted with continued use of ACE inhibitors (OR =0.25; 95% CI, 0.09-0.64) and statins (OR =0.26; 95% CI, 0.08-0.81) throughout the hospital stay. We added further evidence of the beneficial effect of continued use of ACE inhibitors and statins in viral pneumonia.