Utilization of nonbonded interactions involving organoselenium compounds
Utilization of nonbonded interactions involving organoselenium compounds
复制标题
DOI：
10.2174/138527206778521222
复制
发表时间：
2006-10-01
影响因子：
2.6
通讯作者：
Coles, Martyn P.
中科院分区：
文献类型：
--
作者：
Coles, Martyn P.
多年来，人们已经认识到与硒有关的非键相互作用，并已知涉及许多与硫原子形成密切接触的基团和原子。近年来，随着高场核磁共振光谱和单晶X射线衍射技术的显著改进，使得这类技术变得更加容易获得，人们对这些相互作用在硒化学中所起的作用有了进一步的了解。鉴于有机硒化合物在有机化学中的广泛应用，以及人们认识到某些酶途径在活性中心内利用硒，设计一组能够形成Se…Y类型的非键相互作用的新系统构成了一个重要的研究领域，特别是这如何影响与所生成的硒试剂相关的化学。本文旨在总结有机硒化学领域的一些最新进展，特别是在影响观察到的反应活性的结果中涉及到非键相互作用的方面。
Nonbonded interactions involving selenium have been recognized for many years and are known to involve a number of groups and atoms that form close contacts to the chalcogen atom. With substantial improvements in high field NMR spectroscopy and single crystal X-ray diffraction, enabling such techniques to become ever more accessible, further understanding of the role that these interactions play in the chemistry of selenium has been gained in recent years. Given the well documented use of organoselenium compounds in organic chemistry and the recognition that certain enzymatic pathways utilize selenium within the active centre, the design of new systems that incorporate a group able to form nonbonded interactions of the type Se...Y forms an important field of research, with particular interest in how this affects the chemistry associated with the resultant selenium reagent.This article aims to bring together some of the more recent developments in the area of organoselenium chemistry, specifically where the role of nonbonded interactions have been implicated in affecting the outcome of the observed reactivity.