Controlling Crystallization via Organic Solvent Nanofiltration: The Influence of Flux on Griseofulvin Crystallization
Controlling Crystallization via Organic Solvent Nanofiltration: The Influence of Flux on Griseofulvin Crystallization
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DOI：
10.1021/cg401708s
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发表时间：
2014-03
影响因子：
3.8
通讯作者：
J. Campbell;L. Peeva;A. Livingston
中科院分区：
文献类型：
--
作者：
J. Campbell;L. Peeva;A. Livingston
Organic solvent nanofiltration (OSN) is suggested as a method for enhancing crystallization in the pharmaceutical industry. OSN crystallization has the potential to reduce energy and/or chemical inputs and allows for control of process conditions and crystal morphology. This work focuses on the crystallization of the pharmaceutical compound griseofulvin using OSN membranes to concentrate solutions via solvent removal. Griseofulvin solutions were concentrated in a pressure-driven dead-end nanofiltration cell, and crystals were allowed to spontaneously nucleate. The process was carried out using a range of different pressures to manipulate the solvent flux through the membrane. It was found that two distinct crystal types could be produced by altering the process solvent flux. At high flux, large crystals (≈1 mm) were produced, whereas, at low flux, small crystals (2–25 μm), which grew in clustered formations, were observed. The large crystals produced a previously unreported X-ray powder diffraction patter...
