Alteration of cardiac autonomic functions in patients with major depression: A study using heart rate variability measures
Alteration of cardiac autonomic functions in patients with major depression: A study using heart rate variability measures
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DOI：
10.1016/j.jad.2006.10.007
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发表时间：
2007-06-01
影响因子：
6.6
通讯作者：
Gangadhar, B. N.
中科院分区：
文献类型：
--
作者：
Udupa, Kaviraja;Sathyaprabha, T. N.;Gangadhar, B. N.
背景：抑郁症与较高的心脏病发病率和死亡率相关。其中一个促成因素可能是抑郁症患者心脏自主活动的改变。然而，心脏自主神经参与抑郁症仍然是有争议的，因为方法上的问题。在这项研究中，心脏自主神经功能的变化进行了研究，在药物初治的抑郁症患者没有共病。心率变异性，神经心脏自主神经调节的敏感措施，除了使用传统的方法测量心脏自主神经functions.Methods：我们招募了40例患有抑郁症，诊断的DSM-IV-TR标准。他们的心脏自主神经功能的测量使用传统的和心率变异性的措施。这些进行了比较，与年龄和性别匹配的健康controls.Results：抑郁症患者表现出显着较小的Valsalva比，最大/最小比和更大的交感神经平衡比健康对照组，表明减少副交感神经和增加交感神经activity.Conclusions：抑郁症是与心脏自主神经张力的改变，对减少副交感神经活性和增加交感神经活性。这是可能的，一个共同的神经生物学功能障碍有助于抑郁症和心脏自主神经的变化在疾病。(C)2006 Elsevier B. V.保留所有权利。
Background: Depression is associated with greater cardiac morbidity and mortality. One of the contributory factors for this may be altered cardiac autonomic activity in depression. However, cardiac autonomic involvement in depression remains controversial because of methodological issues. In this study, alteration of cardiac autonomic functions was studied in drug-naive patients with major depression without co-morbidity. Heart rate variability, a sensitive measure of neurocardiac autonomic regulation was used in addition to conventional methods of measuring cardiac autonomic functions.Methods: We recruited 40 patients suffering from major depression, diagnosed based on DSM-IV-TR criteria. Their cardiac autonomic functions were measured using both conventional and heart rate variability measures. These were compared with those of age- and gender-matched healthy controls.Results: Patients with major depression showed significantly lesser Valsalva ratio, maximum/minimum ratio and greater sympathovagal balance than healthy controls indicating decreased parasympathetic and increased sympathetic activity.Conclusions: Depression is associated with alteration of cardiac autonomic tone towards decreased parasympathetic activity and an increased sympathetic activity. It is possible that a common neurobiological dysfunction contributes to both depression and cardiac autonomic changes in the illness. (C) 2006 Elsevier B.V. All rights reserved.