Antihypertensive Therapy by ACEI/ARB Is Associated With Intestinal Flora Alterations and Metabolomic Profiles in Hypertensive Patients.
Antihypertensive Therapy by ACEI/ARB Is Associated With Intestinal Flora Alterations and Metabolomic Profiles in Hypertensive Patients.
复制标题
ACEI/ARB 抗高血压治疗与高血压患者肠道菌群改变和代谢组学特征相关
DOI：
10.3389/fcell.2022.861829
复制
发表时间：
2022
影响因子：
5.5
通讯作者：
Li J
中科院分区：
文献类型：
--
作者：
Dong Y;Wang P;Jiao J;Yang X;Chen M;Li J
Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers (ACEI/ARB) are the first-line drugs for the treatment of essential hypertension (HTN), one of the most important risk factors for cardiovascular and cerebrovascular diseases. Intestinal flora and microbial metabolites have been demonstrated to play important roles in blood pressure (BP) regulation and HTN development. However, it remains elusive that intestinal bacteria and metabolites are associated with the protective effects of ACEI/ARB anti-hypertensive drugs against HTN. In this study, we evaluated the effect of ACEI/ARB on gut microbiome and metabolites in patients suffering from HTN. We performed 16S rRNA sequencing and fecal metabolomic analysis of 36 HTN patients placed on ACEI/ARB therapy and 19 newly diagnosed HTN patients with no history of anti-hypertensive treatment. Patients under medication treatment were further classified into well-controlled (n = 24) and poor-controlled (n = 12) groups according to their BP levels. The ACEI/ARB improved the intestinal microbiome of the HTN patients by reducing potentially pathogenic bacteria such as Enterobacter and Klebsiella and increasing beneficial bacteria such as Odoribacter. Moreover, ACEI/ARB therapy was correlated with significant metabolomic changes in the HTN patients, including progressively enhanced inositol from poor-controlled to well-controlled groups. The profiles of gut bacteria were linked to the production of metabolites, and inositol was negatively correlated with Klebsiella, Enterobacter, and Proteobacteria. Our study suggests that ACEI/ARB modulates gut microbial composition and functions and alters microbial metabolites in HTN patients.
登录
查看更多内容
影响因子：
7.3
作者：
Buckley, Charlotte;Wilson, Calum;McCarron, John G.
通讯作者：
McCarron, John G.
影响因子：
24.5
作者：
Jackson MA;Goodrich JK;Maxan ME;Freedberg DE;Abrams JA;Poole AC;Sutter JL;Welter D;Ley RE;Bell JT;Spector TD;Steves CJ
通讯作者：
Steves CJ
影响因子：
8.3
作者：
Gutierrez-Calabres, Elena;Ortega-Hernandez, Adriana;Gomez-Garre, Dulcenombre
通讯作者：
Gomez-Garre, Dulcenombre
影响因子：
6
作者：
Chang, Yanling;Chen, Yunyan;Zhang, Yu
通讯作者：
Zhang, Yu
影响因子：
--
作者：
Göker M;Gronow S;Zeytun A;Nolan M;Lucas S;Lapidus A;Hammon N;Deshpande S;Cheng JF;Pitluck S;Liolios K;Pagani I;Ivanova N;Mavromatis K;Ovchinikova G;Pati A;Tapia R;Han C;Goodwin L;Chen A;Palaniappan K;Land M;Hauser L;Jeffries CD;Brambilla EM;Rohde M;Detter JC;Woyke T;Bristow J;Markowitz V;Hugenholtz P;Eisen JA;Kyrpides NC;Klenk HP
通讯作者：
Klenk HP