Brain structural changes in essential tremor: Voxel-based morphometry at 3-Tesla
Brain structural changes in essential tremor: Voxel-based morphometry at 3-Tesla
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DOI：
10.1016/j.jns.2009.08.037
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发表时间：
2009-12-15
影响因子：
4.4
通讯作者：
Louis, Elan D.
中科院分区：
文献类型：
--
作者：
Benito-Leon, Julian;Alvarez-Linera, Juan;Louis, Elan D.
背景：小脑-丘脑-皮质通路的异常被认为是特发性震颤（ET）的基础。两个基于体素的形态测定（VBM）研究，每个使用1.5 T磁铁，评估ET患者，导致矛盾的结果。使用3-T磁铁，我们评估是否白色或灰质的变化发生在ER患者vs. controls.Methods：我们招募了19例ET患者（平均年龄69.8 +/- 9.4岁）和20名年龄和性别匹配的对照。结果：病例对照比较中，白色改变主要表现在几个区域（右侧小脑、左侧髓质、右侧顶叶和右侧边缘叶）;在几个区域也观察到灰质改变（双侧小脑、双侧顶叶、右额叶和右小脑）（p < 0.001，在体素水平未校正）。与对照组相比，伴有严重震颤的ET患者中脑、枕叶和右额叶有白色物质改变，双侧小脑有灰质改变（p < 0.001，体素水平未校正）。结论：使用VBM和高场MRI扫描仪，ET患者可检测到结构白色和灰色异常。这些变化可能与该病的病理基质有关。(C)2009爱思唯尔有限公司版权所有。
Background: Abnormalities in cerebello-thalamo-cortical pathways have been suggested as a basis for essential tremor (ET). Two voxel-based morphometry (VBM) studies, each using a 1.5-T magnet, evaluated ET patients, leading to contradictory results. Using a 3-T magnet we assessed whether white or gray matter changes occurred in Er patients vs. controls.Methods: We recruited 19 ET patients (mean age 69.8 +/- 9.4 years) and 20 age and gender-matched controls. 3-T MRI data were analyzed using the Statistical Parametric Mapping (SPM) 5 package.Results: In case-control comparisons, white matter changes were seen in several areas (right cerebellum, left medulla, right parietal lobe, and right limbic lobe); gray matter changes were seen in several areas as well (bilateral cerebellum, bilateral parietal lobes, right frontal lobe, and right insula) (p < 0.001, uncorrected at a voxel level). Compared with controls, ET patients with severe tremor had white matter changes in the midbrain, both occipital lobes, and right frontal lobe, and gray matter changes bilaterally in the cerebellum (p < 0.001, uncorrected at a voxel level).Conclusions: Structural white and gray abnormalities may be detected in ET patients using VBM and a high-field MRI scanner. Such changes may be related to the pathological substrates associated with this disease. (C) 2009 Elsevier B.V. All rights reserved.